PCAT-1: A Novel Oncogenic Long Non-Coding RNA in Human Cancers

被引：48
|
作者：
Xiong, Tiefu [1 ]
Li, Jianfa [1 ]
Chen, Fangfang [1 ]
Zhang, Fangting [1 ]
机构：
[1] Peking Univ, Inst Urol, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Shenzhen Hosp, Shenzhen 518036, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2019年 / 15卷 / 04期
关键词：
long non-coding RNA; PCAT-1; cancer; biomarker; therapeutic target; EXPRESSION PROMOTES PROLIFERATION; CELL-PROLIFERATION; PROSTATE-CANCER; GASTRIC-CANCER; HEPATOCELLULAR-CARCINOMA; POOR-PROGNOSIS; UP-REGULATION; COLORECTAL-CANCER; GROWTH ARREST; TUMOR-GROWTH;
D O I：
10.7150/ijbs.30970
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides (nts) without obvious protein coding potential. lncRNAs act as multiple roles in biological processes of diseases, especially carcinomas. Prostate cancer associated transcript-1 (PCAT-1) is an oncogenic lncRNA that identified by RNA-Sequence in prostate cancer. High expression of PCAT-1 is observed in different types of cancers, including prostate cancer, colorectal cancer, hepatocellular cancer and gastric cancer. High expressed PCAT-1 is correlated with poor overall survival. Furthermore, PCAT-1 regulates cancer cell proliferation, apoptosis, migration and invasion. Additionally, PCAT-1 is involved in EMT and Wnt/beta-catenin-signaling pathway. In this review, we focus on the implication of PCAT-1 in human cancers.
引用
收藏
页码：847 / 856
页数：10
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