Increased Placental Nutrient Transporter Expression at Midgestation after Maternal Growth Hormone Treatment in Pigs: A Placental Mechanism for Increased Fetal Growth
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作者:
Tung, Elena
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Univ Adelaide, Robinson Inst, Adelaide, SA 5005, Australia
Univ Adelaide, Sch Paediat & Reprod Hlth, Adelaide, SA 5005, AustraliaUniv Adelaide, Robinson Inst, Adelaide, SA 5005, Australia
Tung, Elena
[1
,2
]
Roberts, Claire T.
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Univ Adelaide, Robinson Inst, Adelaide, SA 5005, Australia
Univ Adelaide, Sch Paediat & Reprod Hlth, Adelaide, SA 5005, AustraliaUniv Adelaide, Robinson Inst, Adelaide, SA 5005, Australia
Roberts, Claire T.
[1
,2
]
Heinemann, Gary K.
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Univ Adelaide, Robinson Inst, Adelaide, SA 5005, Australia
Univ Adelaide, Sch Paediat & Reprod Hlth, Adelaide, SA 5005, AustraliaUniv Adelaide, Robinson Inst, Adelaide, SA 5005, Australia
Heinemann, Gary K.
[1
,2
]
De Blasio, Miles J.
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Univ Adelaide, Robinson Inst, Adelaide, SA 5005, Australia
Univ Adelaide, Sch Paediat & Reprod Hlth, Adelaide, SA 5005, AustraliaUniv Adelaide, Robinson Inst, Adelaide, SA 5005, Australia
De Blasio, Miles J.
[1
,2
]
Kind, Karen L.
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Univ Adelaide, Robinson Inst, Adelaide, SA 5005, Australia
Univ Adelaide, Sch Anim & Vet Sci, Adelaide, SA 5005, AustraliaUniv Adelaide, Robinson Inst, Adelaide, SA 5005, Australia
Kind, Karen L.
[1
,3
]
van Wettere, William H. E. J.
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Univ Adelaide, Sch Anim & Vet Sci, Adelaide, SA 5005, AustraliaUniv Adelaide, Robinson Inst, Adelaide, SA 5005, Australia
van Wettere, William H. E. J.
[3
]
Owens, Julie A.
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Univ Adelaide, Robinson Inst, Adelaide, SA 5005, Australia
Univ Adelaide, Sch Paediat & Reprod Hlth, Adelaide, SA 5005, AustraliaUniv Adelaide, Robinson Inst, Adelaide, SA 5005, Australia
Owens, Julie A.
[1
,2
]
Gatford, Kathryn L.
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Univ Adelaide, Robinson Inst, Adelaide, SA 5005, Australia
Univ Adelaide, Sch Paediat & Reprod Hlth, Adelaide, SA 5005, AustraliaUniv Adelaide, Robinson Inst, Adelaide, SA 5005, Australia
Gatford, Kathryn L.
[1
,2
]
机构:
[1] Univ Adelaide, Robinson Inst, Adelaide, SA 5005, Australia
[2] Univ Adelaide, Sch Paediat & Reprod Hlth, Adelaide, SA 5005, Australia
[3] Univ Adelaide, Sch Anim & Vet Sci, Adelaide, SA 5005, Australia
Growth hormone (GH) is important in maternal adaptation to pregnancy, and maternal circulating GH concentrations are reduced in human growth-restricted pregnancies. In the pig, maternal GH treatment throughout early to mid pregnancy increases fetal growth, despite constraining effects of adolescent and primiparous pregnancy, high litter size, and restricted maternal nutrition. Because GH cannot cross the placenta and does not increase placental weight, we hypothesized that its effects on fetal growth might be via improved placental structure or function. We therefore investigated effects of maternal GH treatment in pigs on structural correlates of placental function and placental expression of nutrient transporters important to fetal growth. Multiparous (sows) and primiparous pregnant pigs (gilts) were treated with GH (similar to 15 mu g kg(-1) day(-1)) or vehicle from Days 25-50 of gestation (n = 7-8 per group, term similar to 115 days). Placentas were collected at Day 50 of gestation, and we measured structural correlates of function and expression of SLC2A1 (previously known as GLUT1) and SLC38A2 (previously known as SNAT2) nutrient transporters. Maternal GH treatment did not alter placental size or structure, increased protein expression of SLC2A1 in trophoblast (+35%; P = 0.037) and on its basal membrane (+44%; P = 0.011), and increased SLC38A2 protein expression in the basal (+44%; P = 0.001) but not the apical cytoplasm of trophoblast. Our findings suggest that maternal GH treatment increases fetal growth, in part, by enhancing placental nutrient transporter protein expression and hence fetal nutrient supply as well as trophoblast proliferation and differentiation and may have the potential to ameliorate intrauterine growth restriction.
机构:
Univ Texas Hlth Sci Ctr San Antonio, Dept OB GYN, San Antonio, TX 78229 USAUniv Texas Hlth Sci Ctr San Antonio, Dept OB GYN, San Antonio, TX 78229 USA
Acosta, Ometeotl
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Lager, Susanne
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Dudley, Donald
Powell, Theresa L.
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Univ Texas Hlth Sci Ctr San Antonio, Dept OB GYN, San Antonio, TX 78229 USAUniv Texas Hlth Sci Ctr San Antonio, Dept OB GYN, San Antonio, TX 78229 USA
Powell, Theresa L.
Jansson, Thomas
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Univ Texas Hlth Sci Ctr San Antonio, Dept OB GYN, San Antonio, TX 78229 USAUniv Texas Hlth Sci Ctr San Antonio, Dept OB GYN, San Antonio, TX 78229 USA