Effects of polysaccharide from Pueraria lobata on gut microbiota in mice

被引：63

作者：

Chen, Rong ^{[1
]}

Liu, Bo ^{[1
]}

Wang, Xiaoyang ^{[1
]}

Chen, Kai ^{[1
]}

Zhang, Keyu ^{[1
]}

Zhang, Lifang ^{[1
]}

Fei, Chenzhong ^{[1
]}

Wang, Chunmei ^{[1
]}

Liu, Yingchun ^{[1
]}

Xue, Feiqun ^{[1
]}

Gu, Feng ^{[1
]}

Wang, Mi ^{[1
]}

机构：

[1] Chinese Acad Agr Sci, Shanghai Vet Res Inst, Key Lab Vet Chem Drugs & Pharmaceut, Minist Agr, Shanghai 200241, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2020年 / 158卷

关键词：

Polysaccharide from Pueraria lobata; Gut microbiota; Short chain fatty acids; CHAIN FATTY-ACIDS; INTESTINAL MICROBIOTA; STRUCTURAL-CHARACTERIZATION; ANTIOXIDANT ACTIVITY; ROOT; PURIFICATION; BACTERIA;

D O I：

10.1016/j.ijbiomac.2020.04.201

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polysaccharide was derived from Pueraria lobata (PPL) which was considered as one of the traditional Chinese medicinal and edible herbs. In the present study, PPL was administered in equal doses (12.5mg/kg) to both normal mice and antibiotic-associated diarrhea (AAD) mice for two weeks, and was evaluated in terms of body weight, organ indices, gut structure, gut microbiota and short chain fatty acids. The results showed that normal mice treated with PPL not only reduced the isovaleric acid concentration (P < 0.05), but also significantly increased the abundance of beneficial bacteria, involving Oscillospira and Anaerotruncus (P < 0.05). In addition, PPL could relieve colonic pathological changes and gut microbiota dysbiosis caused by AAD. It indicated that PPL was a potential functional food ingredient by modulating gut microbiota. (c) 2020 Elsevier B.V. All rights reserved.

引用

收藏

页码：740 / 749

页数：10

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