Multimodal imaging of the self-regulating developing brain

被引：170

作者：

Fjell, Anders M. ^{[1
]}

Walhovd, Kristine Beate ^{[1
]}

Brown, Timothy T. ^{[2
,3
]}

Kuperman, Joshua M. ^{[2
,4
]}

Chung, Yoonho ^{[2
,7
]}

Hagler, Donald J., Jr. ^{[2
,4
]}

Venkatraman, Vijay ^{[2
]}

Roddey, J. Cooper ^{[2
]}

Erhart, Matthew ^{[2
,4
]}

McCabe, Connor ^{[7
]}

Akshoomoff, Natacha ^{[5
,7
]}

Amaral, David G. ^{[8
]}

Bloss, Cinnamon S. ^{[9
,10
]}

Libiger, Ondrej ^{[9
,10
]}

Darst, Burcu F. ^{[9
,10
]}

Schork, Nicholas J. ^{[9
,10
]}

Casey, B. J. ^{[11
]}

Chang, Linda ^{[12
,13
]}

Ernst, Thomas M. ^{[12
,13
]}

Gruen, Jeffrey R. ^{[14
,15
]}

Kaufmann, Walter E. ^{[18
]}

Kenet, Tal ^{[19
,20
]}

Frazier, Jean ^{[21
]}

Murray, Sarah S. ^{[9
,10
]}

Sowell, Elizabeth R. ^{[22
,23
]}

van Zijl, Peter ^{[16
,17
]}

Mostofsky, Stewart

Jernigan, Terry L. ^{[4
,5
,6
,7
]}

Dale, Anders M. ^{[2
,3
,4
,5
,6
]}

机构：

[1] Univ Oslo, Dept Psychol, N-0373 Oslo, Norway

[2] Univ Calif San Diego, Multimodal Imaging Lab, La Jolla, CA 92037 USA

[3] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92037 USA

[4] Univ Calif San Diego, Dept Radiol, La Jolla, CA 92037 USA

[5] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92037 USA

[6] Univ Calif San Diego, Dept Cognit Sci, La Jolla, CA 92037 USA

[7] Univ Calif San Diego, Ctr Human Dev, La Jolla, CA 92037 USA

[8] Univ Calif Davis, Dept Psychiat & Behav Sci, Davis, CA 95817 USA

[9] Scripps Translat Sci Inst, La Jolla, CA 92037 USA

[10] Scripps Hlth, La Jolla, CA 92037 USA

[11] Weill Cornell Med Coll, Sackler Inst Dev Psychobiol, New York, NY 10065 USA

[12] Univ Hawaii, Dept Med, Honolulu, HI 96813 USA

[13] Queens Med Ctr, Honolulu, HI 96813 USA

[14] Yale Univ, Sch Med, Dept Pediat, New Haven, CT 06520 USA

[15] Yale Univ, Sch Med, Dept Genet, New Haven, CT 06520 USA

[16] Johns Hopkins Univ, Sch Med, Kennedy Krieger Inst, FM Kirby Res Ctr, Baltimore, MD 21205 USA

[17] Johns Hopkins Univ, Sch Med, Dept Radiol, Baltimore, MD 21205 USA

[18] Harvard Univ, Sch Med, Childrens Hosp Boston, Boston, MA USA

[19] Massachusetts Gen Hosp, Dept Neurol, Charlestown, MA 02129 USA

[20] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA

[21] Univ Massachusetts, Sch Med, Dept Psychiat, Boston, MA 01655 USA

[22] Univ So Calif, Dept Pediat, Los Angeles, CA 90027 USA

[23] Childrens Hosp, Dev Cognit Neuroimaging Lab, Los Angeles, CA 90027 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2012年 / 109卷 / 48期

基金：

美国国家卫生研究院; 欧洲研究理事会;

关键词：

executive function; cognitive conflict; inhibition; morphometry; WHITE-MATTER INTEGRITY; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; SURFACE-BASED ANALYSIS; ADULT AGE-DIFFERENCES; EXECUTIVE FUNCTIONS; ANTERIOR CINGULATE; CORTICAL THICKNESS; MICROSTRUCTURAL INTEGRITY; FRACTIONAL ANISOTROPY; COGNITIVE CONTROL;

D O I：

10.1073/pnas.1208243109

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Self-regulation refers to the ability to control behavior, cognition, and emotions, and self-regulation failure is related to a range of neuropsychiatric problems. It is poorly understood how structural maturation of the brain brings about the gradual improvement in self-regulation during childhood. In a large-scale multicenter effort, 735 children (4-21 y) underwent structural MRI for quantification of cortical thickness and surface area and diffusion tensor imaging for quantification of the quality of major fiber connections. Brain development was related to a standardized measure of cognitive control (the flanker task from the National Institutes of Health Toolbox), a critical component of self-regulation. Ability to inhibit responses and impose cognitive control increased rapidly during preteen years. Surface area of the anterior cingulate cortex accounted for a significant proportion of the variance in cognitive performance. This finding is intriguing, because characteristics of the anterior cingulum are shown to be related to impulse, attention, and executive problems in neurodevelopmental disorders, indicating a neural foundation for self-regulation abilities along a continuum from normality to pathology. The relationship was strongest in the younger children. Properties of large-fiber connections added to the picture by explaining additional variance in cognitive control. Although cognitive control was related to surface area of the anterior cingulate independently of basic processes of mental speed, the relationship between white matter quality and cognitive control could be fully accounted for by speed. The results underscore the need for integration of different aspects of brain maturation to understand the foundations of cognitive development.

引用

页码：19620 / 19625

页数：6

共 83 条

[1] Assessment and development of executive function (EF) during childhood [J].