Antibiotic and Antimalarial Quinones from Fungus-Growing Ant-Associated Pseudonocardia sp.

被引：82

作者：

Carr, Gavin ^{[1
]}

Derbyshire, Emily R. ^{[1
]}

Caldera, Eric ^{[2
]}

Currie, Cameron R. ^{[2
]}

Clardy, Jon ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

[2] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 10期

关键词：

SELF-RESISTANCE MECHANISM; BETA-GLUCOSYLATION; STREPTOMYCES; BIOSYNTHESIS; BACTERIA; PRODUCTS; STRAIN;

D O I：

10.1021/np300380t

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new members of the angucycline class of antibiotics, pseudonocardones A-C (1-3), along with the known antibiotics 6-deoxy-8-O-methylrabelomycin (4) and X-14881 E (5) have been isolated from the culture of a Pseudonocardia strain associated with the fungus-growing ant Apterostigma dentigerum. Compounds 4 and 5 showed antibiotic activity against Bacillus subtilis 3610 and liver-stage Plasmodium berghei, while 1-3 were inactive or only weakly active in a variety of biological assays. Compound 5 also showed moderate cytotoxicity against HepG2 cells.

引用

页码：1806 / 1809

页数：4

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