The First Synthesis of a Thioglycoside Analogue of the Immunostimulant KRN7000

被引：64

作者：

Dere, Ravindra T. ^{[1
]}

Zhu, Xiangming ^{[1
]}

机构：

[1] Univ Coll Dublin, Sch Chem & Chem Biol, Ctr Synth & Chem Biol, Dublin 4, Ireland

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 20期

基金：

爱尔兰科学基金会;

关键词：

D O I：

10.1021/ol8019555

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of a thioglycoside analogue of KRN7000, a potential immunostimulant, is described. Two key intermediates are alpha-galactosyl thiol 4 and phytosphingosine derivative 5, which were both prepared from D-galactose.

引用

页码：4641 / 4644

页数：4

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