Incidences of overall and site specific cancers in TNFα inhibitor treated patients with rheumatoid arthritis and other arthritides - a follow-up study from the DANBIO Registry

被引：148

作者：

Dreyer, Lene ^{[1
]}

Mellemkjaer, Lene ^{[2
]}

Andersen, Anne Rodgaard ^{[3
,4
]}

Bennett, Philip ^{[5
]}

Poulsen, Uta Engling ^{[6
]}

Ellingsen, Torkell Juulsgaard ^{[7
]}

Hansen, Torben Hoiland ^{[8
]}

Jensen, Dorte Vendelbo ^{[9
]}

Linde, Louise ^{[3
,4
]}

Lindegaard, Hanne Merete ^{[10
]}

Loft, Anne Gitte Rasmussen ^{[11
]}

Nordin, Henrik ^{[12
]}

Omerovic, Emina ^{[13
]}

Rasmussen, Claus ^{[14
]}

Schlemmer, Annette ^{[15
]}

Tarp, Ulrik ^{[16
]}

Hetland, Merete Lund ^{[3
,4
,17
]}

机构：

[1] Gentofte Univ Hosp, Dept Rheumatol, DK-2900 Hellerup, Denmark

[2] Danish Canc Soc, Res Ctr, Copenhagen, Denmark

[3] Glostrup Univ Hosp, DANBIO Registry, Glostrup, Denmark

[4] Glostrup Univ Hosp, Dept Rheumatol, Glostrup, Denmark

[5] Frederiksberg Univ Hosp, Dept Rheumatol, Frederiksberg, Denmark

[6] Univ So Denmark, Rheumatism Hosp, Dept Rheumatol, Grasten, Denmark

[7] Reg Hosp Silkeborg, Ctr Diagnost, Rheumatol Unit, Silkeborg, Denmark

[8] Holbaek Univ Hosp, Dept Rheumatol, Holbaek, Denmark

[9] Helsingborg Hosp, Dept Rheumatol, Helsingor, Denmark

[10] Odense Univ Hosp, Dept Rheumatol, DK-5000 Odense, Denmark

[11] Hosp Lillebaelt, Vejle Hosp, Dept Rheumatol, Vejle, Denmark

[12] Copenhagen Univ Hosp, Rigshosp, Dept Infect Dis & Rheumatol, Copenhagen, Denmark

[13] Koge Hosp, Dept Rheumatol, Koge, Denmark

[14] Vendsyssel Hosp, Dept Rheumatol, Hjorring, Denmark

[15] Aalborg Univ Hosp, Dept Rheumatol, Aalborg, Denmark

[16] Aarhus Univ Hosp, Dept Rheumatol, DK-8000 Aarhus, Denmark

[17] Dept Rheumatol Denmark, Copenhagen, Denmark

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2013年 / 72卷 / 01期

关键词：

NECROSIS FACTOR THERAPY; BIOLOGICS REGISTER; RISK; MALIGNANCIES; METAANALYSIS; LYMPHOMA; COHORT;

D O I：

10.1136/annrheumdis-2012-201969

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives To investigate the incidence of cancer in arthritis patients treated with or without TNF alpha inhibitors (TNF-I). Methods Arthritis patients from the DANBIO database were followed-up for cancer in the Danish Cancer Registry during 2000-2008. Results Hazard ratio for cancer overall was 1.02 (95% confidence interval (CI) 0.80-1.30) in 3347 TNF-I-treated RA patients compared to non-treated. Excess among TNF-I-treated was found for colon cancer (HR 3.52 (95% CI 1.11-11.15), whereas 6 and 0 ovarian cancer cases were observed in treated and non-treated patients, respectively. Compared to the general population, TNF-I-treated RA patients had increased risk for cancer overall, cancer in lymphatic-haematopoietic tissue and non-melanoma skin cancer, while non-RA patients had no increase in overall cancer risk. Conclusions Our results suggest that TNF-I therapy in routine care is not associated with an overall excess of cancer in arthritis patients, but observed increased risks of colon and ovarian cancer need further investigation.

引用

页码：79 / 82

页数：4

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