Acyl-coenzyme A: Cholesterol acyltransferase

被引：418
作者：
Chang, TY
Chang, CCY
Cheng, D
机构：
[1] Department of Biochemistry, Dartmouth Medical School, Hanover
来源：
ANNUAL REVIEW OF BIOCHEMISTRY | 1997年 / 66卷
关键词：
ACAT; cholesteryl esters; allosteric regulation; cholesterol sensors; intracellular cholesterol transport; atherosclerosis;
D O I：
10.1146/annurev.biochem.66.1.613
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Due to its presumed role in regulating cellular cholesterol homeostasis, and in various pathophysiological conditions, acyl-coenzyme A:cholesterol acyltransferase (ACAT) has attracted much attention. Cloning the ACAT gene provides the necessary tool to advance molecular studies of this enzyme. The topics reviewed in this chapter include the pathophysiological roles of ACAT, the biochemistry and molecular biology of the ACAT protein and the ACAT gene, and the mode of regulation by sterol or nonsterol agents in mammalian cells. In addition, we present a working model linking the presumed allosteric property of ACAT with cholesterol trafficking into and out of the endoplasmic reticulum.
引用
收藏
页码：613 / 638
页数：26
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