Synthesis of Novel Amide Derivatives with In Vitro Antiproliferative and Cytotoxic Activity

被引：11
|
作者：
Liu, Ying [1 ]
Zhang, Guo-Yan [1 ]
Li, Yang [2 ]
Zhang, Ya-Nan [1 ]
Zheng, Song-Zhi [1 ]
Zhou, Zhao-Xia [1 ]
An, Sheng-Ji [1 ]
Jin, Ying-Hua [2 ]
机构：
[1] Jilin Univ, Coll Chem, Changchun 130012, Peoples R China
[2] Jilin Univ, Coll Life Sci, Changchun 130012, Peoples R China
来源：
HETEROATOM CHEMISTRY | 2013年 / 24卷 / 01期
关键词：
ANTIMICROBIAL ACTIVITY; MACROCYCLES; INHIBITORS; COMPLEXES; STRATEGY; LIGAND;
D O I：
10.1002/hc.21057
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Some amide derivatives are highly valuable products with antiproliferative and cytotoxic bioactivity. In this paper, 12 novel amide compounds were synthesized correspondingly by boc-protection glycine, deprotection, and condensation reactions. The antiproliferative and cytotoxic activity of these compounds was also evaluated by human cervical cancer (Hela) and hepatoma carcinoma (SK-Hep-1) cancer cell lines. The assay revealed that eight compounds (5ad, 6ad) exhibited activity against Hela cancer cells. Four of them (5ad) also showed activity against SK-Hep-1 cancer cells. (c) 2012 Wiley Periodicals, Inc. Heteroatom Chem 24:917, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.21057
引用
收藏
页码：9 / 17
页数：9
相关论文
共 50 条
  • [1] Synthesis and in vitro antiproliferative activity of novel benzisoselenazolone derivatives
    Xuan, Li-na
    Wang, Peng
    Zhang, Kai
    Shi, Yan-ping
    Liu, Yu-ming
    Zhu, Tao
    Chen, Bao-quan
    MEDICINAL CHEMISTRY RESEARCH, 2015, 24 (02) : 543 - 552
  • [2] Synthesis and in vitro antiproliferative activity of novel benzisoselenazolone derivatives
    Li-na Xuan
    Peng Wang
    Kai Zhang
    Yan-ping Shi
    Yu-ming Liu
    Tao Zhu
    Bao-quan Chen
    Medicinal Chemistry Research, 2015, 24 : 543 - 552
  • [3] Design, synthesis, and in vitro antiproliferative activity of novel Dasatinib derivatives
    Cai, Jin
    Zhang, Shaoning
    Zheng, Ming
    Wu, Xiaoqing
    Chen, Junqing
    Ji, Min
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (02) : 806 - 810
  • [4] Synthesis and Cytotoxic Activity of Novel Resveratrol-Chalcone Amide Derivatives
    Gao, Hui
    Zheng, Xi
    Qi, Wan
    Wang, Si
    Wan, Chunping
    Rao, Gaoxiong
    Mao, Zewei
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018, 38 (03) : 648 - 655
  • [5] SYNTHESIS AND IN VITRO ANTIPROLIFERATIVE ACTIVITY OF NOVEL 2-ARYLIDENEAMINOBENZIMIDAZOLE DERIVATIVES
    Nowicka, Anna
    Liszkiewicz, Hanna
    Nawrocka, Wanda P.
    Wietrzyk, Joanna
    Sadowska, Joanna
    ACTA POLONIAE PHARMACEUTICA, 2015, 72 (05): : 951 - 963
  • [6] Synthesis, characterization, and in vitro antiproliferative activity of novel β-elemene monosubstituted derivatives
    Guifeng Liu
    Zhenwu Kong
    Yumei Shen
    Medicinal Chemistry Research, 2013, 22 : 3536 - 3540
  • [7] Synthesis, characterization, and in vitro antiproliferative activity of novel β-elemene monosubstituted derivatives
    Liu, Guifeng
    Kong, Zhenwu
    Shen, Yumei
    MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (07) : 3536 - 3540
  • [8] Sulfonimide and Amide Derivatives as Novel PPARα Antagonists: Synthesis, Antiproliferative Activity, and Docking Studies
    Ammazzalorso, Alessandra
    Bruno, Isabella
    Florio, Rosalba
    De Lellis, Laura
    Laghezza, Antonio
    Cerchia, Carmen
    De Filippis, Barbara
    Fantacuzzi, Marialuigia
    Giampietro, Letizia
    Maccallini, Cristina
    Tortorella, Paolo
    Veschi, Serena
    Loiodice, Fulvio
    Lavecchia, Antonio
    Cama, Alessandro
    Amoroso, Rosa
    ACS MEDICINAL CHEMISTRY LETTERS, 2020, 11 (05): : 624 - 632
  • [9] Synthesis and In Vitro Cytotoxic Activity of Novel Triazole-Isoxazole Derivatives
    Najafi, Zahra
    Mahdavi, Mohammad
    Safavi, Maliheh
    Saeedi, Mina
    Alinezhad, Heshmatollah
    Pordeli, Mahboobeh
    Ardestani, Sussan Kabudanian
    Shafiee, Abbas
    Foroumadi, Alireza
    Akbarzadeh, Tahmineh
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2015, 52 (06) : 1743 - 1747
  • [10] Synthesis and antiproliferative activity of novel erythromycin derivatives
    Bao, Kai
    Qiao, Foxiao
    Liang, Long
    Li, Hanbing
    Zhu, Huajun
    Zhang, Weige
    Wu, Yingliang
    MEDCHEMCOMM, 2010, 1 (04) : 294 - 298
12345