First use of CRISPR for gene therapy

被引：11

作者：

Jordan, Bertrand ^{[1
,2
]}

机构：

[1] Aix Marseille Univ, EFS, CNRS, UMR 7268,ADES,Espace Eth Mediterraneen,Hop Adulte, 264 Rue St Pierre, F-13385 Marseille 05, France

[2] CoReBio PACA, Case 901,Parc Sci Luminy, F-13288 Marseille 09, France

来源：

M S-MEDECINE SCIENCES | 2016年 / 32卷 / 11期

关键词：

T-CELLS; GENERATION;

D O I：

10.1051/medsci/20163211024

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Two clinical trials using CRISPR technology to engineer the T cells of cancer patients by inactivating the gene for immune checkpoint molecule PD-1 are (almost) underway, one in the USA and the other in China. The less sophisticated Chinese trial seems slated to begin first, in part because of very speedy approval; it may however trigger autoimmune reactions that could be very serious.

引用

页码：1035 / 1037

页数：3

共 11 条

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