Utility of the Neonatal Calf Model for Testing Vaccines and Intervention Strategies for Use against Human RSV Infection

被引：23

作者：

Guerra-Maupome, Mariana ^{[1
]}

Palmer, Mitchell V. ^{[2
]}

McGill, Jodi L. ^{[1
]}

Sacco, Randy E. ^{[3
]}

机构：

[1] Iowa State Univ, Dept Vet Microbiol & Preventat Med, Ames, IA 50011 USA

[2] ARS, Infect Bacterial Dis Livestock Res Unit, Natl Anim Dis Ctr, USDA, Ames, IA 50010 USA

[3] ARS, Ruminant Dis & Immunol Res Unit, Natl Anim Dis Ctr, USDA, Ames, IA 50010 USA

来源：

VACCINES | 2019年 / 7卷 / 01期

基金：

美国农业部; 美国国家卫生研究院;

关键词：

RSV; calf model; human; vaccines; therapeutics; RESPIRATORY SYNCYTIAL VIRUS; T-CELL RESPONSES; NONSTRUCTURAL PROTEINS NS1; F NANOPARTICLE VACCINE; BRONCHOALVEOLAR LAVAGE FLUID; NF-KAPPA-B; ANTIBODY-RESPONSE; FUSION GLYCOPROTEIN; INFLAMMATORY CYTOKINES; INTRANASAL VACCINATION;

D O I：

10.3390/vaccines7010007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Respiratory syncytial virus (RSV) is a significant cause of pediatric respiratory tract infections. It is estimated that two-thirds of infants are infected with RSV during the first year of life and it is one of the leading causes of death in this age group worldwide. Similarly, bovine RSV is a primary viral pathogen in cases of pneumonia in young calves and plays a significant role in bovine respiratory disease complex. Importantly, naturally occurring infection of calves with bovine RSV shares many features in common with human RSV infection. Herein, we update our current understanding of RSV infection in cattle, with particular focus on similarities between the calf and human infection, and the recent reports in which the neonatal calf has been employed for the development and testing of vaccines and therapeutics which may be applied to hRSV infection in humans.

引用

页数：28

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