Sirt1 Def-eating senescence?

被引：49
作者：
Fusco, Salvatore [2 ]
Maulucci, Giuseppe [1 ]
Pani, Giovambattista [2 ]
机构：
[1] Univ Cattolica Sacro Cuore, Sch Med, Inst Phys, I-00168 Rome, Italy
[2] Univ Cattolica Sacro Cuore, Sch Med, Inst Gen Pathol, I-00168 Rome, Italy
来源：
CELL CYCLE | 2012年 / 11卷 / 22期
关键词：
Sirt1; nutrient signaling; calorie restriction; aging; metabolic disease; CR; REPLICATIVE LIFE-SPAN; FATTY-ACID OXIDATION; CALORIE RESTRICTION; CELL-SURVIVAL; REGULATES SIRT1; SKELETAL-MUSCLE; MITOCHONDRIAL-FUNCTION; DEACETYLASE ACTIVITY; INSULIN SENSITIVITY; ACTIVATING SIRT1;
D O I：
10.4161/cc.22074
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Sirt1, the closest mammalian homolog of the Sir2 yeast longevity protein, has been extensively investigated in the last few years as an avenue to understand the connection linking nutrients and energy metabolism with aging and related diseases. From this research effort the picture has emerged of an enzyme at the hub of a complex array of molecular interactions whereby nutrient-triggered signals are translated into several levels of adaptive cell responses, the failure of which underlies diseases as diverse as diabetes, neurodegeneration and cancer. Sirt1 thus connects moderate calorie intake to "healthspan," and a decline of Sirt-centered protective circuits over time may explain the "catastrophic" nature of aging.
引用
收藏
页码：4135 / 4146
页数：12
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