Sirt1 Def-eating senescence?

被引：49

作者：

Fusco, Salvatore ^{[2
]}

Maulucci, Giuseppe ^{[1
]}

Pani, Giovambattista ^{[2
]}

机构：

[1] Univ Cattolica Sacro Cuore, Sch Med, Inst Phys, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Sch Med, Inst Gen Pathol, I-00168 Rome, Italy

来源：

CELL CYCLE | 2012年 / 11卷 / 22期

关键词：

Sirt1; nutrient signaling; calorie restriction; aging; metabolic disease; CR; REPLICATIVE LIFE-SPAN; FATTY-ACID OXIDATION; CALORIE RESTRICTION; CELL-SURVIVAL; REGULATES SIRT1; SKELETAL-MUSCLE; MITOCHONDRIAL-FUNCTION; DEACETYLASE ACTIVITY; INSULIN SENSITIVITY; ACTIVATING SIRT1;

D O I：

10.4161/cc.22074

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sirt1, the closest mammalian homolog of the Sir2 yeast longevity protein, has been extensively investigated in the last few years as an avenue to understand the connection linking nutrients and energy metabolism with aging and related diseases. From this research effort the picture has emerged of an enzyme at the hub of a complex array of molecular interactions whereby nutrient-triggered signals are translated into several levels of adaptive cell responses, the failure of which underlies diseases as diverse as diabetes, neurodegeneration and cancer. Sirt1 thus connects moderate calorie intake to "healthspan," and a decline of Sirt-centered protective circuits over time may explain the "catastrophic" nature of aging.

引用

页码：4135 / 4146

页数：12

共 140 条

[1] Phosphorylation of HuR by Chk2 regulates SIRT1 expression [J].

Abdelmohsen, Kotb ;

Pullmann, Rudolf, Jr. ;

Lai, Ashish ;

Kim, Hyeon Ho ;

Galban, Stefanie ;

Yang, Xiaoling ;

Blethrow, Justin D. ;

Walker, Mark ;

Shubert, Jonathan ;

Gillespie, David A. ;

Furneaux, Henry ;

Gorospe, Myriam .

MOLECULAR CELL, 2007, 25 (04) :543-557

[2] Sirt1 regulates aging and resistance to oxidative stress in the heart [J].

Alcendor, Ralph R. ;

Gao, Shumin ;

Zhai, Peiyong ;

Zablocki, Daniela ;

Holle, Eric ;

Yu, Xianzhong ;

Tian, Bin ;

Wagner, Thomas ;

Vatner, Stephen F. ;

Sadoshima, Junichi .

CIRCULATION RESEARCH, 2007, 100 (10) :1512-1521

[3] CREB and the CRTC co-activators: sensors for hormonal and metabolic signals [J].

Altarejos, Judith Y. ;

Montminy, Marc .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2011, 12 (03) :141-151

[4] Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration [J].

Araki, T ;

Sasaki, Y ;

Milbrandt, J .

SCIENCE, 2004, 305 (5686) :1010-1013

[5] Crosstalk between Components of Circadian and Metabolic Cycles in Mammals [J].

Asher, Gad ;

Schibler, Ueli .

CELL METABOLISM, 2011, 13 (02) :125-137

[6] Can Resveratrol Extend Your Life? [J].

Azzi, Angelo .

IUBMB LIFE, 2009, 61 (10) :1010-1011

[7] Cancer Cell Survival Following DNA Damage-mediated Premature Senescence Is Regulated by Mammalian Target of Rapamycin (mTOR)-dependent Inhibition of Sirtuin 1 [J].

Back, Jung Ho ;

Rezvani, Hamid Reza ;

Zhu, Yucui ;

Guyonnet-Duperat, Veronique ;

Athar, Mohammad ;

Ratner, Desiree ;

Kim, Arianna L. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (21) :19100-19108

[8] Resveratrol improves health and survival of mice on a high-calorie diet [J].

Baur, Joseph A. ;

Pearson, Kevin J. ;

Price, Nathan L. ;

Jamieson, Hamish A. ;

Lerin, Carles ;

Kalra, Avash ;

Prabhu, Vinayakumar V. ;

Allard, Joanne S. ;

Lopez-Lluch, Guillermo ;

Lewis, Kaitlyn ;

Pistell, Paul J. ;

Poosala, Suresh ;

Becker, Kevin G. ;

Boss, Olivier ;

Gwinn, Dana ;

Wang, Mingyi ;

Ramaswamy, Sharan ;

Fishbein, Kenneth W. ;

Spencer, Richard G. ;

Lakatta, Edward G. ;

Le Couteur, David ;

Shaw, Reuben J. ;

Navas, Placido ;

Puigserver, Pere ;

Ingram, Donald K. ;

de Cabo, Rafael ;

Sinclair, David A. .

NATURE, 2006, 444 (7117) :337-342

[9] SIRT1 is a circadian deacetylase for core clock components [J].

Belden, William J. ;

Dunlap, Jay C. .

CELL, 2008, 134 (02) :212-214

[10] Neuron Dysfunction Is Induced by Prion Protein with an Insertional Mutation via a Fyn Kinase and Reversed by Sirtuin Activation in Caenorhabditis elegans [J].

Bizat, Nicolas ;

Peyrin, Jean-Michel ;

Haik, Stephane ;

Cochois, Veronique ;

Beaudry, Patrick ;

Laplanche, Jean-Louis ;

Neri, Christian .

JOURNAL OF NEUROSCIENCE, 2010, 30 (15) :5394-5403

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