Coenzyme Q10 supplementation ameliorates inflammatory signaling and oxidative stress associated with strenuous exercise

被引:54
作者
Diaz-Castro, Javier [1 ,2 ]
Guisado, Rafael [3 ,4 ]
Kajarabille, Naroa [1 ,2 ]
Garcia, Carmen [3 ]
Guisado, Isabel M.
de Teresa, Carlos [5 ]
Ochoa, Julio J. [1 ,2 ]
机构
[1] Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol Jose Mataix Verdu, E-18071 Granada, Spain
[2] Univ Granada, Dept Physiol, E-18071 Granada, Spain
[3] Univ Granada, Fac Hlth Sci, E-18071 Granada, Spain
[4] Univ Granada, Dept Pharmacol, E-18071 Granada, Spain
[5] Andalussian Ctr Sports Med, Seville, Spain
关键词
High-intensity (strenuous) exercise; Coenzyme Q(10); Oxidative damage; Inflammation; NECROSIS-FACTOR-ALPHA; OXYGEN SPECIES FORMATION; MITOCHONDRIAL-FUNCTION; SKELETAL-MUSCLE; FREE-RADICALS; RATS; EXPRESSION; CYTOKINES; OXIDASE; PROTEIN;
D O I
10.1007/s00394-011-0257-5
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Exhausting exercise induces muscle damage associated with high production of free radicals and pro-inflammatory mediators. The objective of this study was to determine for the first time and simultaneously whether oral coenzyme Q(10) (CoQ(10)) supplementation can prevent over-expression of inflammatory mediators and oxidative stress associated with strenuous exercise. The participants were classified in two groups: CoQ(10) group (CG) and placebo group (PG). The physical test consisted in a constant run (50 km) that combined several degrees of high effort (mountain run and ultra-endurance), in permanent climbing. Exercise was associated with an increase in TNF-alpha, IL-6, 8-hydroxy-2'-deoxyguanosine (8-OHdG), and isoprostane levels, revealing the degree of inflammation and oxidative stress induced. Oral supplementation of CoQ(10) during exercise was efficient reducing oxidative stress (decreased membrane hydroperoxides, 8-OHdG and isoprostanes generation, increased catalase, and total antioxidant status), which would lead to the maintenance of the cell integrity. Data obtained also indicate that CoQ(10) prevents over-expression of TNF-alpha after exercise, together with an increase in sTNF-RII that limits the pro-inflammatory actions of TNF. Moreover, CoQ(10) supplementation reduced creatinine production. CoQ(10) supplementation before strenuous exercise decreases the oxidative stress and modulates the inflammatory signaling, reducing the subsequent muscle damage.
引用
收藏
页码:791 / 799
页数:9
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