Structural Characterization and Bacteriostatic and Cytotoxicity to 3T3 Cells Study of Oligobiguanidine (Polyhexamethylene Biguanidine Hydrochloride) and its 3-Glycidoxypropyltrimethoxysilane Derivatives

被引：8

作者：

Jiang, Zhengwu ^{[1
,2
]}

Wang, Bin ^{[1
]}

Che, Hualin ^{[1
]}

Liu, Bailing ^{[1
]}

机构：

[1] Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Sichuan Provinc, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing, Peoples R China

来源：

JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY | 2012年 / 49卷 / 11期

关键词：

Polyhexamethylene biguanidine hydrochloride (PHMB); 3-Glycidoxypropyltrimethoxysilane (GLYMO); antibiotic activity; cytotoxicity; 4-DAY PLAQUE REGROWTH; BACTERIAL COUNTS; POLY(HEXAMETHYLENE BIGUANIDE); CHLORHEXIDINE RINSE; REACTIVE DYES; MOUTHRINSE; PHMB; POLYBIGUANIDES; KERATITIS; EFFICACY;

D O I：

10.1080/10601325.2012.722856

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

In this paper, polyhexamethylene biguanidine hydrochloride (PHMB) oligomers were prepared by polycondensation of hexamethylenediamine, hydrochloric acid and 1,6-hexamethylenebis(dicyanamide); the organosilicon derivatives of PHMB oligomers (PHMB-Si) were prepared in solution through the reaction of PHMB and 3-Glycidoxypropyltrimethoxysilane (GLYMO). The analyses of FT-IR, H-1 and C-13-NMR, elemental analysis, and TGA showed that the PHMB-Si was synthesized successfully. The relationship between antibiotic activity and viscosity-average molecular weight of PHMB; the relationship between antibiotic activity and the content of organosilicon in PHMB-Si were investigated. The experimental results revealed that the antibacterial activity of PHMB yielded the maximum at the viscosity-average molecular weight of 9000. The higher ratio of GLMYO in PHMB-Si, the higher antibiotic activity of PHMB-Si was. The minimal bactericidal concentration (MBC) of PHMB was 10 ppm, and the MBC of PHMB-Si was 5 ppm. The results showed there was an obvious synergy of PHMB-Si in bacteriostatic activity than PHMB.

引用

页码：952 / 962

页数：11

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