Recent advances in the in vitro evolution of nucleic acids

被引：53

作者：

Bittker, JA ^{[1
]}

Phillips, KJ ^{[1
]}

Liu, DR ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Biol Chem, Cambridge, MA 02138 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2002年 / 6卷 / 03期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S1367-5931(02)00321-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Molecular evolution allows chemists and biologists to generate nucleic acids with tailor-made binding or catalytic activities. Recent examples of nucleic acid evolution in vitro provide insights into natural ribozyme evolution and also demonstrate potential applications of evolved DNA and RNA molecules. Efforts to expand the scope of nucleic acid evolution are also underway, including the development of novel methods for exploring nucleic acid sequence-space and the incorporation of non-natural chemical functionality into nucleic acid libraries.

引用

页码：367 / 374

页数：8

共 51 条

[1] Quantitative analysis of receptors for adenosine nucleotides obtained via in vitro selection from a library incorporating a cationic nucleotide analog [J].

Battersby, TR ;

Ang, DN ;

Burgstaller, P ;

Jurczyk, SC ;

Bowser, MT ;

Buchanan, DD ;

Kennedy, RT ;

Benner, SA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (42) :9781-9789

[2] Recombination, RNA evolution, and bifunctional RNA molecules isolated through Chimeric SELEX [J].

Burke, DH ;

Willis, JH .

RNA, 1998, 4 (09) :1165-1175

[3]

CADWELL RC, 1994, PCR METH APPL, V3, pS136

[4] Automated selection of anti-protein aptamers [J].

Cox, JC ;

Ellington, AD .

BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (10) :2525-2531

[5] KINETIC-ANALYSIS OF THE CATALYSIS OF STRAND TRANSFER FROM INTERNAL REGIONS OF HETEROPOLYMERIC RNA TEMPLATES BY HUMAN-IMMUNODEFICIENCY-VIRUS REVERSE-TRANSCRIPTASE [J].

DESTEFANO, JJ .

JOURNAL OF MOLECULAR BIOLOGY, 1994, 243 (04) :558-567

[6] Enhancing the catalytic repertoire of nucleic acids. II. Simultaneous incorporation of amino and imidazolyl functionalities by two modified triphosphates during PCR [J].

Gourlain, T ;

Sidorov, A ;

Mignet, N ;

Thorpe, SJ ;

Lee, SE ;

Grasby, JA ;

Williams, DM .

NUCLEIC ACIDS RESEARCH, 2001, 29 (09) :1898-1905

[7] DNA enzyme targeting TNF-α mRNA improves hemodynamic performance in rats with postinfarction heart failure [J].

Iversen, PO ;

Nicolaysen, G ;

Sioud, M .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2001, 281 (05) :H2211-H2217

[8] RNA-catalyzed RNA polymerization: Accurate and general RNA-templated primer extension [J].

Johnston, WK ;

Unrau, PJ ;

Lawrence, MS ;

Glasner, ME ;

Bartel, DP .

SCIENCE, 2001, 292 (5520) :1319-1325

[9]

Joyce G. F., 1999, COLD SPRING HARBOR M, V37, P49

[10] AMPLIFICATION, MUTATION AND SELECTION OF CATALYTIC RNA [J].

JOYCE, GF .

GENE, 1989, 82 (01) :83-87

← 1 2 3 4 5 6 →