On the antitumor properties of novel cyclometalated benzimidazole Ru(II), Ir(III) and Rh(III) complexes

被引：107

作者：

Yellol, Gorakh S. ^{[1
,2
,3
]}

Donaire, Antonio ^{[1
,2
,3
]}

Yellol, Jyoti G. ^{[1
,2
,3
]}

Vasylyeva, Vera ^{[4
]}

Janiak, Christoph ^{[4
]}

Ruiz, Jose ^{[1
,2
,3
]}

机构：

[1] Univ Murcia, Dept Quim Inorgan, E-30071 Murcia, Spain

[2] Univ Murcia, E-30071 Murcia, Spain

[3] Inst Murciano Invest Biosanitaria, Murcia, Spain

[4] Univ Dusseldorf, Inst Anorgan Chem & Strukturchem, D-40204 Dusseldorf, Germany

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 98期

关键词：

HUMAN SERUM-ALBUMIN; IN-VITRO; INHIBITION;

D O I：

10.1039/c3cc46239k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Smart design and efficient synthesis of benzimidazole Ru, Ir and Rh cyclometalated complexes are reported with promising cytotoxic activity against HT29, T47D, A2780 and A2780cisR cancer cell lines. Their apoptosis, accumulation, cell cycle arrest, protein binding and DNA binding effects are also discussed.

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收藏

页码：11533 / 11535

页数：3

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