Angiogenesis and skin carcinomas with skull base invasion: A case-control study

被引：9

作者：

Cernea, CR ^{[1
]}

Ferraz, AR

de Castro, IV

Sotto, MN

Logullo, AF

Bacchi, CE

Potenza, AS

机构：

[1] Univ Sao Paulo, Sch Med, Dept Head & Neck Surg, Sao Paulo, Brazil

[2] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo, Brazil

[3] Univ Fed Sao Paulo, Dept Pathol, Sao Paulo, Brazil

[4] Sao Paulo State Univ, Dept Pathol, Botucatu, SP, Brazil

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2004年 / 26卷 / 05期

关键词：

angiogenesis; basal cell carcinoma; squamous cell carcinoma; base of skull; immunohistochemistry;

D O I：

10.1002/hed.10399

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. Some skin carcinomas may be very aggressive. Intensity of angiogenesis, measured by intratumoral vessel density using expression of CD34, has been associated with tumor aggressiveness. In this study, the expression of CD34 in basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) with skull base invasion was compared with that in tumors with good outcome. Methods. Expression of CD34 was graded as mild, moderate, and intense, in 24 BCCs and 11 SCCs with skull base invasion. The control group included 23 BCCs and 10 SCCs. Results. Intense expression of CD34 was noted in 25.00% of BCCs with skull base invasion, compared with 4.35% in the control group (p =.058). Regarding SCCs, intense expression of CD34 was found in 54.55% of aggressive tumors, compared with 10.00% in the control group (p = 133). Conclusions. A trend toward denser microvascular angiogenesis was observed in both BCCs and SCCs with skull base invasion compared with less aggressive controls. (C) 2004 Wiley Periodicals, Inc.

引用

页码：396 / 400

页数：5

共 24 条

[11]

Freeman R G, 1976, J Dermatol Surg, V2, P215

[12]

GOWN AM, 1993, APPL IMMUNOHISTO M M, V1, P256

[13] Cellular proliferation characteristics do not account for the behaviour of horrifying basal cell carcinoma. A comparison of the growth fraction of horrifying and non horrifying tumours [J].

Horlock, N ;

Wilson, GD ;

Daley, FM ;

Richman, PI ;

Grobbelaar, AO ;

Sanders, R ;

Foy, C .

BRITISH JOURNAL OF PLASTIC SURGERY, 1998, 51 (01) :59-66

[14] USE OF AVIDIN-BIOTIN-PEROXIDASE COMPLEX (ABC) IN IMMUNOPEROXIDASE TECHNIQUES - A COMPARISON BETWEEN ABC AND UNLABELED ANTIBODY (PAP) PROCEDURES [J].

HSU, SM ;

RAINE, L ;

FANGER, H .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1981, 29 (04) :577-580

[15]

JACKSON R, 1973, Journal of Surgical Oncology, V5, P431, DOI 10.1002/jso.2930050505

[16]

LANG PG, 1991, CANC SKIN, P35

[17]

McNamara DA, 1998, BRIT J SURG, V85, P1044

[18]

Petruzzelli GJ, 1996, HEAD NECK-J SCI SPEC, V18, P283

[19]

Ruhoy SM, 2001, SURGICAL PATHOLOGY OF THE HEAD AND NECK, SECOND EDITION, VOLS 1-3, P1793

[20] The prognostic significance of tumor angiogenesis in nonaggressive and aggressive basal cell carcinoma of the human skin [J].

Staibano, S ;

Boscaino, A ;

Salvatore, G ;

Orabona, P ;

Palombini, L ;

DeRosa, G .

HUMAN PATHOLOGY, 1996, 27 (07) :695-700

← 1 2 3 →