A copper-free Sonogashira coupling reaction in ionic liquids and its application to a microflow system for efficient catalyst recycling

被引：381

作者：

Fukuyama, T ^{[1
]}

Shinmen, M ^{[1
]}

Nishitani, S ^{[1
]}

Sato, M ^{[1
]}

Ryu, I ^{[1
]}

机构：

[1] Osaka Prefecture Univ, Dept Chem, Fac Arts & Sci, Sakai, Osaka 5998531, Japan

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 10期

关键词：

D O I：

10.1021/ol0257732

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The PdCl2(PPh3)(2)-catalyzed Sonogashira coupling reaction, in good to high yields, was performed in an ionic liquid ([BMIm][PF6]) in the absence of a copper salt. The use of an ionic liquid allows for the facile separation and recycling of the catalyst. The application of the above reaction in a microflow system in conjunction with an IMM micromixer was also successful.

引用

页码：1691 / 1694

页数：4

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