Localization, anchoring and translational control of oskar, gurken, bicoid and nanos mRNA during Drosophila oogenesis

被引:113
作者
Kugler, Jan-Michael [1 ]
Lasko, Paul [1 ]
机构
[1] McGill Univ, Dept Biol, Montreal, PQ H3A 1B1, Canada
关键词
Drosophila; oogenesis; mRNA localization; mRNA anchoring; translational regulation; oskar; gurken; bicoid; nanos; EMBRYONIC AXIS SPECIFICATION; POLAR GRANULE COMPONENTS; BINDING-PROTEIN; POSTERIOR LOCALIZATION; CYTOPLASMIC POLYADENYLATION; CYTOSKELETAL ORGANIZATION; MICROTUBULE ORGANIZATION; REGULATES TRANSLATION; HNRNPA/B HOMOLOG; OOCYTE POLARITY;
D O I
10.4161/fly.3.1.7751
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
mRNA localization, and translation that is regulated spatially and temporally, are key mechanisms in the execution of polarized developmental programs. For over two decades, the Drosophila oocyte has served as a valuable model to study these mechanisms. Genetic and biochemical studies in flies have greatly contributed to the identification and understanding of factors that govern RNA localization and translational control. Embryonic axis formation is mediated through the subcellular localization and precise translational regulation of four key determinant mRNAs during oogenesis encoded by oskar, bicoid, gurken and nanos. In this review we aim to summarize recent insights into the mechanisms governing the asymmetric distribution and translation of these mRNAs.
引用
收藏
页码:15 / 28
页数:14
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