Renin-angiotensin system genes in kidney development

被引:1
|
作者
Harris, JM [1 ]
Gomez, RA [1 ]
机构
[1] UNIV VIRGINIA,HLTH SCI CTR,DIV NEPHROL,CHARLOTTESVILLE,VA 22908
关键词
renin-angiotensin system; cardiovascular homeostasis; kidney function; renal growth and development;
D O I
10.1002/(SICI)1097-0029(19971101)39:3<211::AID-JEMT2>3.0.CO;2-N
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
The renin-angiotensin system (RAS) plays a key role in cardiovascular homeostasis through the interactions of angiotensin II with its receptors. All components of the RAS are developmentally regulated in the kidney. The functions of the system in the maturing kidney overlap those of the adult, but higher levels of expression and novel locations of expression in the fetus suggest that the RAS has alternate functions as well. Increasing evidence suggests that the RAS may regulate renal growth and development by initiating a complex cascade of events, involving growth factors and proto-oncogenes and other unidentified factors. These same cascades may also be important in renal disease states. Recent advances in the field of molecular and cell biology are providing new tools and strategies to elucidate the intimate mechanisms whereby the RAS regulates growth processes and disease states. (C) 1997 Wiley-Liss, Inc.
引用
收藏
页码:211 / 221
页数:11
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