Transfer of autoimmune thyroiditis and resolution of palmoplantar pustular psoriasis following allogeneic bone marrow transplantation

被引：56

作者：

Kishimoto, Y ^{[1
]}

Yamamoto, Y ^{[1
]}

Ito, T ^{[1
]}

Matsumoto, N ^{[1
]}

Ichiyoshi, H ^{[1
]}

Katsurada, T ^{[1
]}

Date, M ^{[1
]}

Ohga, S ^{[1
]}

Kitajima, H ^{[1
]}

Ikehara, S ^{[1
]}

Fukuhara, S ^{[1
]}

机构：

[1] KANSAI MED UNIV,DEPT PATHOL 1,MORIGUCHI,OSAKA 570,JAPAN

来源：

BONE MARROW TRANSPLANTATION | 1997年 / 19卷 / 10期

关键词：

autoimmune thyroiditis; palmoplantar pustular psoriasis; bone marrow transplantation; autoimmunity;

D O I：

10.1038/sj.bmt.1700789

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We report an unusual case of a patient who was cured of one autoimmune disease (palmoplantar pustular psoriasis (PPP)) but developed another autoimmune disease (autoimmune thyroiditis) after allogeneic BMT. A 40-year-old man suffering from AML with PPP underwent allogeneic BMT from his HLA-identical sister for the treatment of AML. The patient experienced complete clearance of the cutaneous PPP despite the cessation of immunosuppressive therapy for over 2 years, However, he developed hyperthyroidism with anti-thyroglobulin antibodies 5 months after BMT, although he had showed normal thyroid functions without anti-thyroglobulin antibodies before BMT, The donor had no history of thyroid diseases and showed normal thyroid functions but was positive for anti-thyroglobulin antibodies, Thus, even when the donor is in a subclinical state, autoimmune thyroiditis may be transferred from donors to recipients by BMT.

引用

页码：1041 / 1043

页数：3

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