Clinical implications of the results of recent atherothrombotic trials on patient management

被引:1
作者
Betriu, Amadeo [1 ]
机构
[1] Hosp Clin Barcelona, Dept Cardiol, Hemodynam Unit, E-08036 Barcelona, Spain
关键词
Acute coronary syndrome; Percutaneous coronary intervention; Atherothrombotic trials; Glycoprotein IIb/IIIa inhibitors; Heparin; Clopidogrel;
D O I
10.1093/eurheartj/sun040
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Significant advances have been made over the last several years in the treatment of patients with acute coronary syndromes including the introduction and approval of new antithrombin and antiplatelet agents. Results from a number of studies have impacted treatment strategies of patients with and without percutaneous coronary intervention. The study design and results of five trials: OASIS-5 PCI, PCI-ACUITY, TRITON-TIMI-38, FINESSE, and CARESS-in-AMI will be reviewed, and implications for clinical practice presented.
引用
收藏
页码:30 / 32
页数:3
相关论文
共 8 条
[1]  
Bassand JP, 2007, EUR HEART J, V28, P1598, DOI 10.1093/eurheartj/ehm161
[2]   Immediate angioplasty versus standard therapy with rescue 3 angioplasty after thrombolysis in the Combined Abciximab REteplase Stent Study in Acute Myocardial Infarction (CARESS-in-AMI): an open, prospective, randomised, multicentre trial [J].
Di Mario, Carlo ;
Dudek, Dariusz ;
Piscione, Federico ;
Mielecki, Waldemar ;
Savonitto, Stefano ;
Murena, Ernesto ;
Dimopoulos, Konstantinos ;
Manari, Antonio ;
Gaspardone, Achille ;
Ochala, Andrzej ;
Zmudka, Krzysztof ;
Bolognese, Leonardo ;
Steg, Philippe Gabriel ;
Flather, Marcus .
LANCET, 2008, 371 (9612) :559-568
[3]   Facilitated PCI in patients with ST-elevation myocardial infarction [J].
Ellis, Stephen G. ;
Tendera, Michal ;
de Belder, Mark A. ;
van Boven, Ad J. ;
Widimsky, Petr ;
Janssens, Luc ;
Andersen, H. R. ;
Betriu, Amadeo ;
Savonitto, Stefano ;
Adamus, Jerzy ;
Peruga, Jan Z. ;
Kosmider, Maciej ;
Katz, Olivier ;
Neunteufl, Thomas ;
Jorgova, Julia ;
Dorobantu, Maria ;
Grinfeld, Liliana ;
Armstrong, Paul ;
Brodie, Bruce R. ;
Herrmann, Howard C. ;
Montalescot, Gilles ;
Neumann, Franz-Josef ;
Effron, Mark B. ;
Barnathan, Elliot S. ;
Topol, Eric J. .
NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (21) :2205-2217
[4]   The SYNERGY trial: Study design and rationale [J].
Ferguson, JJ ;
Califf, RM ;
Antman, EM ;
Cohen, M ;
Grines, CL ;
Kereiakes, DJ ;
Langer, A ;
Mahaffey, KW ;
Nessel, CC ;
Rios-Nogales, L .
AMERICAN HEART JOURNAL, 2002, 143 (06) :952-960
[5]   Efficacy and safety of fondaparinux versus Enoxaparin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: Results from the OASIS-5 trial [J].
Mehta, Shamir R. ;
Granger, Christopher B. ;
Eikelboom, John W. ;
Bassand, Jean-Pierre ;
Wallentin, Lars ;
Faxon, David P. ;
Peters, Ron J. G. ;
Budaj, Andrzej ;
Afzal, Rizwan ;
Chrolavicius, Susan ;
Fox, Keith A. A. ;
Yusuf, Salim .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 50 (18) :1742-1751
[6]   Bivalirudin in patients with acute coronary syndromes undergoing percutaneous coronary intervention: a subgroup analysis from the Acute Catheterization and Urgent Intervention Triage strategy (ACUITY) trial [J].
Stone, Gregg W. ;
White, Harvey D. ;
Ohman, E. Magnus ;
Bertrand, Michel E. ;
Lincoff, A. Michael ;
McLaurin, Brent T. ;
Cox, David A. ;
Pocock, Stuart J. ;
Ware, James H. ;
Feit, Frederick ;
Colombo, Antonio ;
Manoukian, Steven V. ;
Lonsky, Alexandra J. ;
Mehran, Roxana ;
Moses, Jeffrey W. .
LANCET, 2007, 369 (9565) :907-919
[7]  
WIDIMSKY P, 2008, EUR HEART J
[8]   Prasugrel versus clopidogrel in patients with acute coronary syndromes [J].
Wiviott, Stephen D. ;
Braunwald, Eugene ;
McCabe, Carolyn H. ;
Montalescot, Gilles ;
Ruzyllo, Witold ;
Gottlieb, Shmuel ;
Neumann, Franz-Joseph ;
Ardissino, Diego ;
De Servi, Stefano ;
Murphy, Sabina A. ;
Riesmeyer, Jeffrey ;
Weerakkody, Govinda ;
Gibson, C. Michael ;
Antman, Elliott M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (20) :2001-2015