Synthesis and In Vitro Cytotoxic Evaluation of 7-Chloro-4-anilino-quinoline Amide Derivatives

被引：0

作者：

Bui Trung Hieu ^{[1
]}

Vu Thu Thuy ^{[1
]}

Hoang Xuan Tien ^{[1
]}

Tran Khac Vu ^{[1
]}

机构：

[1] Hanoi Univ Sci & Technol, Dept Pharmaceut Chem & Pesticides Technol, Sch Chem Engn, Hanoi, Vietnam

来源：

ASIAN JOURNAL OF CHEMISTRY | 2013年 / 25卷 / 08期

关键词：

Anticancer; Amide; Cell line; Cytotoxic; Quinoline; QUINOLINES;

D O I：

10.14233/ajchem.2013.14016

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of new amide derivatives of 4-anilino-quinoline have been synthesized and evaluated in vitro cytotoxic activity against the human hepatocellular carcinoma (HepG2), human lung carcinoma (SK-LU-1) and human breast cancer (MCF-7). Compound 5g was found to be most potent cytotoxic activity against HepG2 and MCF-7 cell lines with IC50 values of 2.09 and 4.63 mu g/mL, respectively. Compound 5e exhibited significant cytotoxic activity against three cell lines with IC50 values ranging from 5-10 mu g/mL.

引用

页码：4453 / 4456

页数：4

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