Functional Analysis of the Plant Chromosomal Passenger Complex1[OPEN]

被引：23
作者：
Komaki, Shinichiro [1 ,2 ]
Takeuchi, Hidenori [3 ,4 ]
Hamamura, Yuki [2 ]
Heese, Maren [2 ]
Hashimoto, Takashi [1 ]
Schnittger, Arp [2 ]
机构：
[1] Nara Inst Sci & Technol, Grad Sch Biol Sci, Ikoma, Nara 6300192, Japan
[2] Univ Hamburg, Inst Plant Sci & Microbiol, Dept Dev Biol, D-22609 Hamburg, Germany
[3] Nagoya Univ, World Premier Int Res Ctr Initiat, Inst Transformat BioMol WPI ITbM, Nagoya, Aichi 4648601, Japan
[4] Nagoya Univ, Inst Adv Res, Nagoya, Aichi 4648602, Japan
来源：
PLANT PHYSIOLOGY | 2020年 / 183卷 / 04期
基金：
日本学术振兴会;
关键词：
CELL-DIVISION CONTROL; AURORA KINASES; COMPLEX CPC; ARABIDOPSIS; INCENP; SURVIVIN; SPINDLE; GENE; PHOSPHORYLATION; CENTROMERE;
D O I：
10.1104/pp.20.00344
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A Borealin homolog in Arabidopsis functions as a part of the chromosome passenger complex. The Aurora B kinase, encoded by theAURORA 3(AUR3) gene in Arabidopsis (Arabidopsis thaliana), is a key regulator of cell division in all eukaryotes. Aurora B has at least two central functions during cell division; it is essential for the correct, i.e. balanced, segregation of chromosomes in mitosis and meiosis by controlling kinetochore function, and it acts at the division plane, where it is necessary to complete cytokinesis. To accomplish these two spatially distinct functions, Aurora B in animals is guided to its sites of action by Borealin, inner centromere protein (INCENP), and Survivin, which, together with Aurora B, form the chromosome passenger complex (CPC). However, besides Aurora homologs, only a candidate gene with restricted homology to INCENP has been described in Arabidopsis, raising the question of whether a full complement of the CPC exists in plants and how Aurora homologs are targeted subcellularly. Here, we have identified and functionally characterized a Borealin homolog, BOREALIN RELATED (BORR), in Arabidopsis. Together with detailed localization studies including the putative Arabidopsis INCENP homolog, these results support the existence of a CPC in plants.
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收藏
页码：1586 / 1599
页数：14
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