The rate of opening and closing of the DNA gate for topoisomerase II

被引：1

作者：

Ding, Hui ^{[1
]}

Lin, Hao ^{[1
]}

Feng, Juan ^{[1
]}

机构：

[1] Univ Elect Sci & Technol China, Key Lab NeuroInformat, Minist Educ, Ctr Bioinformat,Sch Life Sci & Technol, Chengdu 610054, Peoples R China

来源：

THEORY IN BIOSCIENCES | 2013年 / 132卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Type II DNA topoisomerases; ATP release; The rate of the opening and closing; Master equation theory; STEADY-STATE ANALYSIS; ATP; MECHANISM; HYDROLYSIS; TRANSPORT;

D O I：

10.1007/s12064-012-0163-2

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Type II DNA topoisomerases can catalyze the transport of one DNA segment through a transient break in another DNA segment by a complex mechanism of ATP hydrolysis. According to the hydrolysis process of two ATPs, a multi-state model is proposed to investigate the work cycle of DNA topoisomerase II. The rate of the opening and closing of the DNA topoisomerase gate is evaluated by determining the release rate of inorganic phosphates. The calculated results show that, under the condition of the high concentration of ATP, the work cycle of DNA topoisomerase II is about 0.84 s which is in agreement with the experimental data.

引用

收藏

页码：61 / 64

页数：4

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