New targets for treatment against HCV infection

被引：2

作者：

Pan, Qiuwei ^{[1
]}

van der Laan, Luc J. W. ^{[2
,3
]}

机构：

[1] Erasmus MC, Univ Med Ctr, Dept Gastroenterol & Hepatol, NL-3015 CE Rotterdam, Netherlands

[2] Erasmus MC, Univ Med Ctr, Dept Surg, NL-3015 CE Rotterdam, Netherlands

[3] Erasmus MC, Univ Med Ctr, Lab Expt Transplantat & Intestinal Surg, NL-3015 CE Rotterdam, Netherlands

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2012年 / 26卷 / 04期

关键词：

New therapeutic target; HCV entry; HCV replication; HCV genome; HEPATITIS-C-VIRUS; BROADLY NEUTRALIZING ANTIBODIES; RNA REPLICATION COMPLEX; B TYPE-I; CYCLOSPORINE-A; NONSTRUCTURAL PROTEINS; LIVER-TRANSPLANTATION; ENTRY; CYCLOPHILIN; BINDING;

D O I：

10.1016/j.bpg.2012.10.002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Owing to the tremendous effort from both academia and industry, drug development for hepatitis C virus (HCV) infection has been flourishing, with a range of pipeline compounds at various stages of development. Although combination of the recently launched serine protease inhibitors will further improve the response rate of current interferon-based therapy, some intrinsic limitations of these compounds and the tendency of resistance development by the virus, urge the development of alternative or additional therapeutic strategies. In this article we provide an overview of different host and viral factors which have emerged as new potential targets for therapeutic intervention using state-of-the-art technologies. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：505 / 515

页数：11

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