Hepatic lipase: new insights from genetic and metabolic studies

被引：119

作者：

Cohen, JC

Vega, GL

Grundy, SM

机构：

[1] Univ Texas, SW Med Ctr, Ctr Human Nutr, Dallas, TX 75235 USA

[2] Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75235 USA

[3] Univ Texas, SW Med Ctr, Dept Clin Nutr, Dallas, TX 75235 USA

来源：

CURRENT OPINION IN LIPIDOLOGY | 1999年 / 10卷 / 03期

关键词：

D O I：

10.1097/00041433-199906000-00008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatic lipase catalyses the hydrolysis of triglycerides and phospholipids in all major Glasses of lipoproteins. Genetic deficiency of this enzyme is associated with a unique plasma lipoprotein profile, characterized by hypertriglyceridemia and elevated concentrations of intermediate density lipoproteins and HDL. Recent studies have identified common polymorphisms in the hepatic lipase gene that are associated with low hepatic lipase activity and increased concentrations of large HDL. Association studies using these polymorphisms are elucidating the effects of variation in hepatic lipase activity on plasma lipoprotein concentrations and susceptibility to coronary atherosclerosis. Curr Opin Lipidol 10:259-267. (C) 1999 Lippincott Williams & Wilkins.

引用

页码：259 / 267

页数：9

共 63 条

[31] Common C-to-T substitution at position -480 of the hepatic lipase promoter associated with a lowered lipase activity in coronary artery disease patients [J].