High quinolone resistance pattern among enteric pathogens isolated from patients with urinary tract infection

Urinary tract infection (UTI) is one of the most common infections that exists in all age groups. It is predominantly caused by members of the family Enterobacteriaceae, such as, Eseherichia coil, Klebsiella, Enterobacter and Proteus. Quinolones have been routinely prescribed for the treatment of UTIs and this has led to a dramatic increase in antibiotic resistance by these uropathogens. The aim of the present study was to determine the quinolone resistance pattern in enteric pathogens isolated from UTI patients in Maharishi Markandeshwar University (MMU), Mullana, Haryana. Clinical samples were obtained from MMU Medical College. A total of 70 samples were screened, 60 isolates (41 and 19 from female and male, respectively) were confirmed as those belonging to the family Enterobacteriaceae. About 63.41% of the female patients belonged to the age group 21-40 yr, while men in the age group of 41-80 yr, were found to be more prone to UTI infections (68.4%) Minimum inhibitory concentration (MIC) of the isolates against ciprofloxacin, norfloxacin, ofloxacin and levofloxacin was determined. About 93% of the isolates were resistant to all the antibiotics. Further, 16% of the isolates exhibited MICs higher than 1000 mg/L against ciprofloxacin and 59% against norfloxacin.