Synthesis, DNA-binding and photocleavage studies of cobalt(III) mixed-ligand complexes

被引：13
|
作者：
Zhang, QL
Xu, H
Li, H
Liu, J
Liu, JZ
Ji, LN [1 ]
Liu, JG
机构：
[1] Zhongshan Univ, Dept Chem, State Key Lab Ultrafast Laser Spect, Key Lab Gene Engn,Minist Educ, Guangzhou 510275, Peoples R China
[2] Tongji Univ, Dept Chem, Shanghai 200092, Peoples R China
来源：
TRANSITION METAL CHEMISTRY | 2002年 / 27卷 / 02期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1023/A:1013967324592
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Two novel complex ions [Co(bpy)(2)IP](3+) and [Co(bpy)(2)PIP](3+), have been prepared and characterized by EA, mass spectra, u.v.-vis., and cyclic voltammetry. The binding behavior of both complexes to calf thymus DNA (CT-DNA) has been investigated by spectroscopic methods, cyclic voltammetry, and viscosity measurements. The results suggest that both complexes bind to DNA by intercalation. Both promote cleavage of plasmid pBR 322 DNA from the supercoiled Form I to the open circular Form II upon irradiation. Mechanisms for photocleavage are proposed.
引用
收藏
页码：149 / 154
页数：6
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