Autism Profiles of Males With Fragile X Syndrome

被引：293

作者：

Harris, Susan W. ^{[1
,2
]}

Hessl, David ^{[3
]}

Goodlin-Jones, Beth ^{[3
]}

Ferranti, Jessica ^{[3
]}

Bacalman, Susan

Barbato, Ingrid ^{[4
]}

Tassone, Flora ^{[5
]}

Hagerman, Paul J. ^{[5
]}

Herman, Kristin ^{[2
]}

Hagerman, Randi J. ^{[2
]}

机构：

[1] Univ Calif Davis, Med Ctr, UC Davis Hlth Syst, MIND Inst, Sacramento, CA 95817 USA

[2] Univ Calif Davis, Med Ctr, Dept Pediat, Sacramento, CA 95817 USA

[3] Univ Calif Davis, Med Ctr, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA

[4] Neurogene Clin Lab, Florianopolis, SC, Brazil

[5] Univ Calif Davis, Sch Med, Dept Biochem & Mol Med, Sacramento, CA 95817 USA

来源：

AMERICAN JOURNAL ON MENTAL RETARDATION | 2008年 / 113卷 / 06期

关键词：

D O I：

10.1352/2008.113:427-438

中图分类号：

G76 [特殊教育];

学科分类号：

040109 ;

摘要：

Autism, which is common in individuals with fragile X syndrome, is often difficult to diagnose. We compared the diagnostic classifications of two measures for autism diagnosis, the ADOS and the ADI-R, in addition to the DSM-IV-TR in 63 males with this syndrome. Overall, 30% of the subjects met criteria for autistic disorder and 30% met criteria for PDD-NOS. The classifications on the ADOS and DSM-IV-TR were most similar, whereas the ADI-R classified subjects as autistic much more frequently. We further investigated the relationship of both FMRP and FMR1 mRNA to symptoms of autism in this cohort and found no significant relationship between the measures of autism and molecular features, including FMRP, FMR1 mRNA, and CGG repeat number.

引用

页码：427 / 438

页数：12

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