Autism Profiles of Males With Fragile X Syndrome

被引:292
作者
Harris, Susan W. [1 ,2 ]
Hessl, David [3 ]
Goodlin-Jones, Beth [3 ]
Ferranti, Jessica [3 ]
Bacalman, Susan
Barbato, Ingrid [4 ]
Tassone, Flora [5 ]
Hagerman, Paul J. [5 ]
Herman, Kristin [2 ]
Hagerman, Randi J. [2 ]
机构
[1] Univ Calif Davis, Med Ctr, UC Davis Hlth Syst, MIND Inst, Sacramento, CA 95817 USA
[2] Univ Calif Davis, Med Ctr, Dept Pediat, Sacramento, CA 95817 USA
[3] Univ Calif Davis, Med Ctr, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA
[4] Neurogene Clin Lab, Florianopolis, SC, Brazil
[5] Univ Calif Davis, Sch Med, Dept Biochem & Mol Med, Sacramento, CA 95817 USA
来源
AMERICAN JOURNAL ON MENTAL RETARDATION | 2008年 / 113卷 / 06期
关键词
D O I
10.1352/2008.113:427-438
中图分类号
G76 [特殊教育];
学科分类号
040109 ;
摘要
Autism, which is common in individuals with fragile X syndrome, is often difficult to diagnose. We compared the diagnostic classifications of two measures for autism diagnosis, the ADOS and the ADI-R, in addition to the DSM-IV-TR in 63 males with this syndrome. Overall, 30% of the subjects met criteria for autistic disorder and 30% met criteria for PDD-NOS. The classifications on the ADOS and DSM-IV-TR were most similar, whereas the ADI-R classified subjects as autistic much more frequently. We further investigated the relationship of both FMRP and FMR1 mRNA to symptoms of autism in this cohort and found no significant relationship between the measures of autism and molecular features, including FMRP, FMR1 mRNA, and CGG repeat number.
引用
收藏
页码:427 / 438
页数:12
相关论文
共 65 条
  • [1] American Psychiatric Association, 2000, DSM-IV-TR, VFourth
  • [2] Clinical features of boys with fragile X premutations and intermediate alleles
    Aziz, M
    Stathopulu, E
    Callias, M
    Taylor, C
    Turk, J
    Oostra, B
    Willemsen, R
    Patton, M
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2003, 121B (01) : 119 - 127
  • [3] Bailey DB, 1998, J AUTISM DEV DISORD, V28, P499
  • [4] Bailey DB, 2001, J AUTISM DEV DISORD, V31, P165
  • [5] Bailey DB, 2000, J AUTISM DEV DISORD, V30, P49
  • [6] The amygdala theory of autism
    Baron-Cohen, S
    Ring, HA
    Bullmore, ET
    Wheelwright, S
    Ashwin, C
    Williams, SCR
    [J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2000, 24 (03) : 355 - 364
  • [7] BAUMGARDNER TL, 1995, PEDIATRICS, V95, P744
  • [8] Fragile X syndrome and autism at the intersection of genetic and neural networks
    Belmonte, Matthew K.
    Bourgeron, Thomas
    [J]. NATURE NEUROSCIENCE, 2006, 9 (10) : 1221 - 1225
  • [9] The phenotypic manifestations of interstitial duplications of proximal 15q with special reference to the autistic spectrum disorders
    Bolton, PF
    Dennis, NR
    Browne, CE
    Thomas, NS
    Veltman, MWM
    Thompson, RJ
    Jacobs, P
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS, 2001, 105 (08): : 675 - 685
  • [10] FRAGILE-X AND AUTISM - A MULTICENTER SURVEY
    BROWN, WT
    JENKINS, EC
    COHEN, IL
    FISCH, GS
    WOLFSCHEIN, EG
    GROSS, A
    WATERHOUSE, L
    FEIN, D
    MASONBROTHERS, A
    RITVO, E
    RUTTENBERG, BA
    BENTLEY, W
    CASTELLS, S
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS, 1986, 23 (1-2): : 341 - 352