Gold-Nanoparticle-Encapsulated ZIF-8 for a Mediator-Free Enzymatic Glucose Sensor by Amperometry

被引：114

作者：

Paul, Anirban ^{[1
,2
]}

Vyas, Gaurav ^{[1
,2
]}

Paul, Parimal ^{[1
,2
]}

Srivastava, Divesh N. ^{[1
,2
]}

机构：

[1] CSMCRI, CSIR, Analyt & Environm Sci Div, GB Marg, Bhavnagar 364002, Gujarat, India

[2] CSMCRI, CSIR, AcSIR, GB Marg, Bhavnagar 364002, Gujarat, India

来源：

ACS APPLIED NANO MATERIALS | 2018年 / 1卷 / 07期

关键词：

ZIF-8; gold nanoparticles; encapsulation; amperometry; enzymatic glucose sensor; tandem catalyst; ZEOLITIC IMIDAZOLATE FRAMEWORKS; METAL-ORGANIC FRAMEWORK; OXIDASE; SIZE; FUNCTIONALITY; ADSORPTION; BIOSENSORS; CRYSTALS; SYSTEM;

D O I：

10.1021/acsanm.8b00748

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

A novel method has been developed for the encapsulation of gold nanoparticles (AuNPs) and glucose oxidase (GOx) together into the cavity of a zeolitic imidazolate framework (ZIF-8) in aqueous media and subsequently used for amperometric glucose sensing application. ZIF-8 is a highly efficient, stable (thermally and chemically) microstructure and possesses a large surface area with a unique cavity to accommodate both AuNPs and GOx. The as-synthesized composite is thoroughly characterized by various physicochemical methods and confirms the uniform distribution of AuNPs within the metal-organic framework cavity. The presence of highly conducting AuNPs enhances the activity of GOx and facilitates the mediator-free tandem electrocatalytic reactions of both glucose oxidation and oxygen reduction. Further, the nanocomposite exhibits admirable stability with low-level detection of glucose in aqueous media (SO nM glucose) by using a very low concentration of GOx (62 mu g in 1 mL).

引用

页码：3600 / 3607

页数：15

共 43 条

[31] Adsorption and Diffusion Phenomena in Crystal Size Engineered ZIF-8 MOF [J].