Variable results after rituximab in neuromyelitis optica

被引：54

作者：

Lindsey, J. W. ^{[1
]}

Meulmester, K. M. ^{[1
]}

Brod, S. A. ^{[1
]}

Nelson, F. ^{[1
]}

Wolinsky, J. S. ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr Houston, Dept Neurol, Houston, TX 77030 USA

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2012年 / 317卷 / 1-2期

关键词：

Neuromyelitis optica; Rituximab; Case series; Therapy; Neuroimmunology;

D O I：

10.1016/j.jns.2012.02.017

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Our objective was to assess the efficacy of rituximab (RTX) in neuromyelitis optica (NMO). We conducted a retrospective review of cases personally treated by the authors. We identified nine subjects meeting criteria for either NMO or recurrent longitudinally extensive transverse myelitis (LETM) who were treated with RTX and documented their clinical course. Six of the nine subjects continued to have relapses after RTX treatment. RTX was the first immunosuppressive treatment used after diagnosis in five subjects, and four of these continued to have relapses. We conclude that outcomes after RTX treatment of NMO are inconsistent. The observed variability may reflect differences in disease activity between individuals, differences in disease activity over time, or differences in the underlying immunopathogenesis of NMO. More effective treatments are needed. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：103 / 105

页数：3

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