Synthesis and antimicrobial activity of tri-substituted 1,6-dihydropyrimidines

被引:0
作者
Ramesh, B. [1 ]
Bharathi, D. R. [1 ]
Basavaraj, H. S. [1 ]
Jayadevaiah, K. V. [1 ]
机构
[1] Sri Adichunchanagiri Coll Pharm, Dept Pharmaceut Chem, Balagangadharanatha Naga 571448, India
关键词
synthesis; 1,6-dihydropyrimidines; microwave; antibacterial activity;
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A series of substituted 1,6-dihydropyrimidines compounds have been synthesized by the reaction of ethylcyanoacetate, thiourea and substituted aldehydes in the presence of potassium carbonate and ethanol. Reactions have been carried out by conventional and microwave methods. The synthesized compounds are screened for their antibacterial and antifungal activity against Staphylococcus aureus, Escherichia coli and Candida albicans, Aspergillus flavus, respectively.
引用
收藏
页码:2591 / 2596
页数:6
相关论文
共 20 条
[1]  
Basavaraj HS, 2005, INDIAN J HETEROCY CH, V15, P69
[2]  
Cheng C C, 1969, Prog Med Chem, V6, P67
[3]   2-4-DIAMINOPYRIMIDINES - A NEW SERIES OF ANTIMALARIALS [J].
FALCO, EA ;
GOODWIN, LG ;
HITCHINGS, GH ;
ROLLO, IM ;
RUSSELL, PB .
BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1951, 6 (02) :185-200
[4]   APPLICATIONS OF COMBINATORIAL TECHNOLOGIES TO DRUG DISCOVERY .2. COMBINATORIAL ORGANIC-SYNTHESIS, LIBRARY SCREENING STRATEGIES, AND FUTURE-DIRECTIONS [J].
GORDON, EM ;
BARRETT, RW ;
DOWER, WJ ;
FODOR, SPA ;
GALLOP, MA .
JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (10) :1385-1401
[5]   Solid-phase organic reactions .2. A review of the literature Nov 95 Nov 96. [J].
Hermkens, PHH ;
Ottenheijm, HCJ ;
Rees, DC .
TETRAHEDRON, 1997, 53 (16) :5643-5678
[6]  
HOWELLS RE, 1981, ACTA TROP, V38, P289
[7]   Biologically active dihydropyrimidones of the Biginelli-type - a literature survey [J].
Kappe, CO .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2000, 35 (12) :1043-1052
[8]  
KIDWAI M, 2000, CHEM ED REV, V154, P34
[9]  
KOOS M, 1994, CHEM PAP-CHEM ZVESTI, V48, P108
[10]   APPLICATIONS OF MICROWAVE DIELECTRIC HEATING EFFECTS TO SYNTHETIC PROBLEMS IN CHEMISTRY [J].
MINGOS, DMP ;
BAGHURST, DR .
CHEMICAL SOCIETY REVIEWS, 1991, 20 (01) :1-47