Dynamic combinatorial libraries constructed on polymer scaffolds

被引：39
作者：
Fulton, David A. [1 ]
机构：
[1] Univ Newcastle Upon Tyne, Sch Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 15期
关键词：
D O I：
10.1021/ol8011309
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Functionalized polymers were prepared by grafting acylhydrazides onto a polyvinylbenzaldehyde scaffold through reversible hydrazone linkages. The dynamic nature of these linkages allows the functionalized polymers to exchange and reshuffle their appendages, and the resultant mixture of polymers can be considered as a dynamic combinatorial library constructed upon a polymer scaffold. The dynamic nature of these functionalized polymers was demonstrated.
引用
收藏
页码：3291 / 3294
页数：4
相关论文
共 39 条
  • [1] Berg J. M., 2002, BIOCHEMISTRY-US, P41
  • [2] Dynamic combinatorial chemistry
    Corbett, Peter T.
    Leclaire, Julien
    Vial, Laurent
    West, Kevin R.
    Wietor, Jean-Luc
    Sanders, Jeremy K. M.
    Otto, Sijbren
    [J]. CHEMICAL REVIEWS, 2006, 106 (09) : 3652 - 3711
  • [3] Correlation between host-guest binding and host amplification in simulated dynamic combinatorial libraries
    Corbett, PT
    Otto, S
    Sanders, JKM
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 2004, 10 (13) : 3139 - 3143
  • [4] What are the limits to the size of effective dynamic combinatorial libraries?
    Corbett, PT
    Otto, S
    Sanders, JKM
    [J]. ORGANIC LETTERS, 2004, 6 (11) : 1825 - 1827
  • [5] Nucleophilic catalysis of hydrazone formation and transimination: Implications for dynamic covalent chemistry
    Dirksen, Anouk
    Dirksen, Sjoerd
    Hackeng, Tilman M.
    Dawson, Philip E.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (49) : 15602 - 15603
  • [6] Nucleophilic catalysis of oxime ligation
    Dirksen, Anouk
    Hackeng, Tilman M.
    Dawson, Philip E.
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (45) : 7581 - 7584
  • [7] Adaptive behavior of dynamic combinatorial libraries generated by assembly of different building blocks
    Grote, Z
    Scopelliti, R
    Severin, K
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (32) : 3821 - 3825
  • [8] New polymer synthesis by nitroxide mediated living radical polymerizations
    Hawker, CJ
    Bosman, AW
    Harth, E
    [J]. CHEMICAL REVIEWS, 2001, 101 (12) : 3661 - 3688
  • [9] Dynamic formation of graft polymers via radical crossover reaction of alkoxyamines
    Higaki, Y
    Otsuka, H
    Takahara, A
    [J]. MACROMOLECULES, 2004, 37 (05) : 1696 - 1701
  • [10] Well-defined polymers with activated ester and protected aldehyde side chains for bio-functionalization
    Hwang, Jungyeon
    Li, Ronald C.
    Maynard, Heather D.
    [J]. JOURNAL OF CONTROLLED RELEASE, 2007, 122 (03) : 279 - 286
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