Dynamic combinatorial libraries constructed on polymer scaffolds

被引：39

作者：

Fulton, David A. ^{[1
]}

机构：

[1] Univ Newcastle Upon Tyne, Sch Chem, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 15期

关键词：

D O I：

10.1021/ol8011309

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Functionalized polymers were prepared by grafting acylhydrazides onto a polyvinylbenzaldehyde scaffold through reversible hydrazone linkages. The dynamic nature of these linkages allows the functionalized polymers to exchange and reshuffle their appendages, and the resultant mixture of polymers can be considered as a dynamic combinatorial library constructed upon a polymer scaffold. The dynamic nature of these functionalized polymers was demonstrated.

引用

页码：3291 / 3294

页数：4

共 39 条

[1]

Berg J. M., 2002, BIOCHEMISTRY-US, P41

[2] Dynamic combinatorial chemistry [J].

Corbett, Peter T. ;

Leclaire, Julien ;

Vial, Laurent ;

West, Kevin R. ;

Wietor, Jean-Luc ;

Sanders, Jeremy K. M. ;

Otto, Sijbren .

CHEMICAL REVIEWS, 2006, 106 (09) :3652-3711

[3] Correlation between host-guest binding and host amplification in simulated dynamic combinatorial libraries [J].

Corbett, PT ;

Otto, S ;

Sanders, JKM .

CHEMISTRY-A EUROPEAN JOURNAL, 2004, 10 (13) :3139-3143

[4] What are the limits to the size of effective dynamic combinatorial libraries? [J].

Corbett, PT ;

Otto, S ;

Sanders, JKM .

ORGANIC LETTERS, 2004, 6 (11) :1825-1827

[5] Nucleophilic catalysis of hydrazone formation and transimination: Implications for dynamic covalent chemistry [J].

Dirksen, Anouk ;

Dirksen, Sjoerd ;

Hackeng, Tilman M. ;

Dawson, Philip E. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (49) :15602-15603

[6] Nucleophilic catalysis of oxime ligation [J].

Dirksen, Anouk ;

Hackeng, Tilman M. ;

Dawson, Philip E. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (45) :7581-7584

[7] Adaptive behavior of dynamic combinatorial libraries generated by assembly of different building blocks [J].

Grote, Z ;

Scopelliti, R ;

Severin, K .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (32) :3821-3825

[8] New polymer synthesis by nitroxide mediated living radical polymerizations [J].

Hawker, CJ ;

Bosman, AW ;

Harth, E .

CHEMICAL REVIEWS, 2001, 101 (12) :3661-3688

[9] Dynamic formation of graft polymers via radical crossover reaction of alkoxyamines [J].

Higaki, Y ;

Otsuka, H ;

Takahara, A .

MACROMOLECULES, 2004, 37 (05) :1696-1701

[10] Well-defined polymers with activated ester and protected aldehyde side chains for bio-functionalization [J].

Hwang, Jungyeon ;

Li, Ronald C. ;

Maynard, Heather D. .

JOURNAL OF CONTROLLED RELEASE, 2007, 122 (03) :279-286

← 1 2 3 4 →