Gene and protein expressions of type I collagen are regulated tissue-specifically in rat hyaline cartilages in vivo

被引：5
|
作者：
Sasano, Y [1 ]
Takahashi, I
Zhu, JX
Ohtani, H
Mizoguchi, I
Kagayama, M
机构：
[1] Tohoku Univ, Sch Dent, Dept Oral Anat 2, Sendai, Miyagi 9808575, Japan
[2] Tohoku Univ, Sch Dent, Dept Orthodont, Sendai, Miyagi, Japan
[3] Tohoku Univ, Sch Med, Dept Pathol, Sendai, Miyagi, Japan
[4] Hlth Sci Univ Hokkaido, Dept Orthodont, Sch Dent, Tobetsu Ishikari, Hokkaido, Japan
来源：
EUROPEAN JOURNAL OF MORPHOLOGY | 2001年 / 39卷 / 03期
关键词：
articular cartilage; growth plate cartilage; tracheal cartilage; nasal septum cartilage; type I collagen; in situ hybridization; immunohistochemistry;
D O I：
10.1076/ejom.39.3.149.4675
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
The present study was designed to investigate how rat hyaline cartilages at various sites in vivo express the gene and protein of type I collagen using in situ hybridization and immuno-histochemistry. The gene of pro alpha 1(I) collagen was expressed by chondrocytes in articular cartilage, and the protein of type I collagen was identified in the cartilage matrix. In contrast, growth plate cartilage expressed the gene of pro alpha 1(I) collagen, but no protein of type I collagen. Neither gene nor protein of type I collagen was expressed in cartilages of trachea and nasal septum. The present study suggested that expression of type I collagen in hyaline cartilages may be regulated tissue-specifically at gene and/or protein levels.
引用
收藏
页码：149 / 154
页数：6
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