Multisite phosphorylation and the countdown to S phase

被引：114

作者：

Deshaies, RJ ^{[1
]}

Ferrell, JE

机构：

[1] Stanford Univ, Sch Med, Dept Mol Pharmacol, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Biochem, Stanford, CA 94305 USA

[3] CALTECH, Div Biol, Pasadena, CA 91125 USA

[4] CALTECH, Howard Hughes Med Inst, Pasadena, CA 91125 USA

来源：

CELL | 2001年 / 107卷 / 07期

关键词：

D O I：

10.1016/S0092-8674(01)00620-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Remarkably, SCFCdc4 ubiquitin ligase binds and ubiquitinates Sic1 decorated with six, but not five, phosphates (Nash et al., 2001). This numerical wizardry suggests how analog inputs can be rectified to digital outputs. Unraveling the counting mechanism promises to generate new insights into the architecture of protein nanoprocessors.

引用

页码：819 / 822

页数：4

共 20 条

[11] Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication [J].

Nash, P ;

Tang, XJ ;

Orlicky, S ;

Chen, QH ;

Gertler, FB ;

Mendenhall, MD ;

Sicheri, F ;

Pawson, T ;

Tyers, M .

NATURE, 2001, 414 (6863) :514-521

[12] Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms [J].

Nguyen, VQ ;

Co, C ;

Li, JJ .

NATURE, 2001, 411 (6841) :1068-1073

[13] Linkage of replication to start by the Cdk inhibitor Sic1 [J].

Schneider, BL ;

Yang, QH ;

Futcher, AB .

SCIENCE, 1996, 272 (5261) :560-562

[14] THE B-TYPE CYCLIN KINASE INHIBITOR P40(SIC1) CONTROLS THE G1 TO S TRANSITION IN SACCHAROMYCES-CEREVISIAE [J].

SCHWOB, E ;

BOHM, T ;

MENDENHALL, MD ;

NASMYTH, K .

CELL, 1994, 79 (02) :233-244

[15] F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex [J].

Skowyra, D ;

Craig, KL ;

Tyers, M ;

Elledge, SJ ;

Harper, JW .

CELL, 1997, 91 (02) :209-219

[16] Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line [J].

Strohmaier, H ;

Spruck, CH ;

Kaiser, P ;

Won, KA ;

Sangfelt, O ;

Reed, SI .

NATURE, 2001, 413 (6853) :316-322

[17]

VALLEN EA, 1995, MOL CELL BIOL, V15, P4291

[18] Phosphorylation of Sic1p by G(1) Cdk required for its degradation and entry into S phase [J].

Verma, R ;

Annan, RS ;

Huddleston, MJ ;

Carr, SA ;

Reynard, G ;

Deshaies, RJ .

SCIENCE, 1997, 278 (5337) :455-460

[19] Selective degradation of ubiquitinated Sic1 by purified 26S proteasome yields active S phase cyclin-Cdk [J].

Verma, R ;

McDonald, H ;

Yates, JR ;

Deshaies, RJ .

MOLECULAR CELL, 2001, 8 (02) :439-448

[20] F-box/WD-repeat proteins Pop1p and Sud1p/Pop2p form complexes that bind and direct the proteolysis of Cdc18p [J].

Wolf, DA ;

McKeon, F ;

Jackson, PK .

CURRENT BIOLOGY, 1999, 9 (07) :373-376

← 1 2 →