Multisite phosphorylation and the countdown to S phase

被引：114

作者：

Deshaies, RJ ^{[1
]}

Ferrell, JE

机构：

[1] Stanford Univ, Sch Med, Dept Mol Pharmacol, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Biochem, Stanford, CA 94305 USA

[3] CALTECH, Div Biol, Pasadena, CA 91125 USA

[4] CALTECH, Howard Hughes Med Inst, Pasadena, CA 91125 USA

来源：

CELL | 2001年 / 107卷 / 07期

关键词：

D O I：

10.1016/S0092-8674(01)00620-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Remarkably, SCFCdc4 ubiquitin ligase binds and ubiquitinates Sic1 decorated with six, but not five, phosphates (Nash et al., 2001). This numerical wizardry suggests how analog inputs can be rectified to digital outputs. Unraveling the counting mechanism promises to generate new insights into the architecture of protein nanoprocessors.

引用

页码：819 / 822

页数：4

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