MiR-135a functions as a selective killer of malignant glioma

被引：78
作者：
Wu, S. [1 ]
Lin, Y. [1 ]
Xu, D. [1 ]
Chen, J. [1 ]
Shu, M. [1 ]
Zhou, Y. [1 ]
Zhu, W. [1 ]
Su, X. [1 ]
Zhou, Y. [1 ]
Qiu, P. [1 ]
Yan, G. [1 ]
机构：
[1] Sun Yat Sen Univ, Dept Pharmacol, Zhongshan Sch Med, Guangzhou 510080, Guangdong, Peoples R China
来源：
ONCOGENE | 2012年 / 31卷 / 34期
基金：
中国国家自然科学基金;
关键词：
malignant glioma; microRNA; apoptosis; nucleic-acid drug; PROSTATE-CANCER CELLS; GENE-EXPRESSION; SELF-RENEWAL; APOPTOSIS; MICRORNAS; MOUSE; IDENTIFICATION; PROLIFERATION; DISRUPTION; ACTIVATION;
D O I：
10.1038/onc.2011.551
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glioma is the most common and fatal primary brain tumor. Thus far, therapeutic strategies to efficiently and specifically antagonize glioma are limited and poorly developed. Here we report that glia-enriched miR-135a, a microRNA that is dramatically downregulated in malignant glioma and correlated with the pathological grading, is capable of inducing mitochondria-dependent apoptosis of malignant glioma by regulating various genes including STAT6, SMAD5 and BMPR2, as well as affecting the signaling pathway downstream. Moreover, this lethal effect is selectively towards malignant glioma cells, but not neurons and glial cells, through a novel mechanism. Our findings suggest an important role of miR-135a in glioma etiology and provide a potential candidate for malignant glioma therapy. Oncogene (2012) 31, 3866-3874; doi:10.1038/onc.2011.551; published online 5 December 2011
引用
收藏
页码：3866 / 3874
页数：9
相关论文
共 38 条
[1]   Opinion - Survivin, cancer networks and pathway-directed drug discovery [J].
Altieri, Dario C. .
NATURE REVIEWS CANCER, 2008, 8 (01) :61-70
[2]   Active targeting of brain tumors using nanocarriers [J].
Beduneau, Arnaud ;
Saulnier, Patrick ;
Benoit, Jean-Pierre .
BIOMATERIALS, 2007, 28 (33) :4947-4967
[3]   Disruption of Transient Receptor Potential Canonical Channel 1 Causes Incomplete Cytokinesis and Slows the Growth of Human Malignant Gliomas [J].
Bomben, Valerie C. ;
Sontheimer, Harald .
GLIA, 2010, 58 (10) :1145-1156
[4]   Biochemical pathways of caspase activation during apoptosis [J].
Budihardjo, I ;
Oliver, H ;
Lutter, M ;
Luo, X ;
Wang, XD .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1999, 15 :269-290
[5]   Characterization of microRNA expression levels and their biological correlates in human cancer cell lines [J].
Gaur, Arti ;
Jewell, David A. ;
Liang, Yu ;
Ridzon, Dana ;
Moore, Jason H. ;
Chen, Caifu ;
Ambros, Victor R. ;
Israel, Mark A. .
CANCER RESEARCH, 2007, 67 (06) :2456-2468
[6]   miR-122, a paradigm for the role of microRNAs in the liver [J].
Girard, Muriel ;
Jacquemin, Emmanuel ;
Munnich, Arnold ;
Lyonnet, Stanislas ;
Henrion-Caude, Alexandra .
JOURNAL OF HEPATOLOGY, 2008, 48 (04) :648-656
[7]   Targeting of the Bmi-1 Oncogene/Stem Cell Renewal Factor by MicroRNA-128 Inhibits Glioma Proliferation and Self-Renewal [J].
Godlewski, Jakub ;
Nowicki, Michal O. ;
Bronisz, Agnieszka ;
Williams, Shante ;
Otsuki, Akihiro ;
Nuovo, Gerard ;
RayChaudhury, Abhik ;
Newton, Herbert B. ;
Chiocca, E. Antonio ;
Lawler, Sean .
CANCER RESEARCH, 2008, 68 (22) :9125-9130
[8]   nhl-2 Modulates MicroRNA Activity in Caenorhabditis elegans [J].
Hammell, Christopher M. ;
Lubin, Isabella ;
Boag, Peter R. ;
Blackwell, T. Keith ;
Ambros, Victor .
CELL, 2009, 136 (05) :926-938
[9]   miRNAMap 2.0: genomic maps of microRNAs in metazoan genomes [J].
Hsu, Sheng-Da ;
Chu, Chia-Huei ;
Tsou, Ann-Ping ;
Chen, Shu-Jen ;
Chen, Hua-Chien ;
Hsu, Paul Wei-Che ;
Wong, Yung-Hao ;
Chen, Yi-Hsuan ;
Chen, Gian-Hung ;
Huang, Hsien-Da .
NUCLEIC ACIDS RESEARCH, 2008, 36 :D165-D169
[10]   miR2Disease: a manually curated database for microRNA deregulation in human disease [J].
Jiang, Qinghua ;
Wang, Yadong ;
Hao, Yangyang ;
Juan, Liran ;
Teng, Mingxiang ;
Zhang, Xinjun ;
Li, Meimei ;
Wang, Guohua ;
Liu, Yunlong .
NUCLEIC ACIDS RESEARCH, 2009, 37 :D98-D104
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