Palladium-catalyzed C-allylation of benzoins and an NHC-catalyzed three component coupling derived thereof: Compatibility of NHC- and Pd-catalysts

被引：99

作者：

Lebeuf, Raphael ^{[1
]}

Hirano, Keiichi ^{[1
]}

Glorius, Frank ^{[1
]}

机构：

[1] Univ Munster, Organ Chem Inst Westfal, D-48149 Munster, Germany

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 19期

关键词：

D O I：

10.1021/ol801644f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A large range of benzoins was successfully applied as C-nucleophiles in the palladium-catalyzed allylic alkylation with several allyl acetates, resulting in functionalized tertiary homoallylic alcohols. A number of unsymmetrical benzoins can be coupled with high levels of regio- and chemoselectivity. Finally, the challenging compatibility of free N-heterocyclic carbenes with a palladium catalyst has been utilized in a number of metal- and organocatalyzed three-component coupling reactions.

引用

页码：4243 / 4246

页数：4

共 39 条

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