Insights on methotrexate in psoriatic disease

被引：10

作者：

Greb, Jacqueline E. ^{[1
,2
]}

Goldminz, Ari M. ^{[1
,2
]}

Gottlieb, Alice B. ^{[2
]}

机构：

[1] Tufts Med Ctr, Dept Dermatol, 800 Washington St,Box 114, Boston, MA 02111 USA

[2] Tufts Univ, Sch Med, 136 Harrison Ave, Boston, MA 02111 USA

来源：

CLINICAL IMMUNOLOGY | 2016年 / 172卷

关键词：

Methotrexate; Psoriasis; Psoriatic arthritis; Adenosine; T-cell; Cardiovascular disease; ONSET RHEUMATOID-ARTHRITIS; PLACEBO-CONTROLLED TRIAL; T-CELLS; CARDIOVASCULAR-DISEASE; PATHOGENIC MECHANISMS; MYOCARDIAL-INFARCTION; ADENOSINE RELEASE; CLINICAL-TRIAL; DOUBLE-BLIND; EXPRESSION;

D O I：

10.1016/j.clim.2016.07.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The folic acid analogue methotrexate is used as an anti-neoplastic agent and treatment for inflammatory disorders including psoriasis, dermatomyositis, lupus erythematous, sarcoidosis, and systemic sclerosis. Despite the introduction of newer biologic agents, methotrexate remains a first-line systemic therapy for many patients with disorders of chronic inflammation. Here we briefly describe the current clinical evidence for methotrexate use in psoriatic disease, our current understanding of methotrexate's anti-inflammatory properties, and the future role of methotrexate in the treatment of immune mediated disorders. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：61 / 64

页数：4

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