Intramolecular arylcyanation of alkenes catalyzed by nickel/AlMe2CI

被引：220

作者：

Nakao, Yoshiaki ^{[1
]}

Ebata, Shiro ^{[1
]}

Yada, Akira ^{[1
]}

Hiyama, Tamejiro ^{[1
]}

Ikawa, Masashi ^{[2
]}

Ogoshi, Sensuke ^{[2
]}

机构：

[1] Kyoto Univ, Dept Chem Mat, Kyoto, Japan

[2] Osaka Univ, Dept Appl Chem, Osaka, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 39期

关键词：

D O I：

10.1021/ja805088r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A catalyst system derived from nickel and cocatalytic AlMe2Cl effects the intramolecular arylcyanation of alkenes. The reaction takes place in an exclusive exo-dig manner to give a wide range of nitrites having a benzylic quaternary carbon in good yields. Detailed investigations are described on the scope and mechanism as well as preliminary results on the asymmetric version of the reaction to provide novel access to chiral quaternary stereocenters.

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页码：12874 / +

页数：3

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