"Self-Immolative" Spacer for Uncaging with Fluorescence Reporting

被引：37
|
作者：
Labruere, Raphael [1 ,2 ,3 ]
Alouane, Ahmed [1 ,2 ,3 ]
Le Saux, Thomas [2 ]
Aujard, Isabelle [2 ]
Pelupessy, Philippe [4 ]
Gautier, Arnaud [2 ]
Dubruille, Sylvie [1 ,3 ]
Schmidt, Frederic [1 ,3 ]
Jullien, Ludovic [2 ]
机构：
[1] Inst Curie, Ctr Rech, F-75248 Paris, France
[2] Ecole Normale Super, Dept Chim, UMR CNRS ENS UPMC PASTEUR 8640, F-75231 Paris, France
[3] UMR 176, F-75248 Paris, France
[4] Ecole Normale Super, Dept Chim, UMR CNRS UPMC ENS Lab Biomol 7203, F-75231 Paris, France
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 37期
关键词：
caging groups; fluorescence; imaging agents; kinetics; self-immolative spacers; PHOTOCHEMICAL CONTROL; RELEASE; DENDRIMERS; CHEMISTRY; LIGANDS; DESIGN; SYSTEM;
D O I：
10.1002/anie.201204032
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Dual photoliberation: A caged, branched, self-immolative spacer (see scheme, gray box) was designed to rapidly and simultaneously release a desired compound (green) and a fluorophore (red) upon photoactivation. Careful kinetic analysis of the disassembly of the spacer shows that it occurs on the shortest time scale reported to date. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：9344 / 9347
页数：4
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