"Self-Immolative" Spacer for Uncaging with Fluorescence Reporting

被引：37

作者：

Labruere, Raphael ^{[1
,2
,3
]}

Alouane, Ahmed ^{[1
,2
,3
]}

Le Saux, Thomas ^{[2
]}

Aujard, Isabelle ^{[2
]}

Pelupessy, Philippe ^{[4
]}

Gautier, Arnaud ^{[2
]}

Dubruille, Sylvie ^{[1
,3
]}

Schmidt, Frederic ^{[1
,3
]}

Jullien, Ludovic ^{[2
]}

机构：

[1] Inst Curie, Ctr Rech, F-75248 Paris, France

[2] Ecole Normale Super, Dept Chim, UMR CNRS ENS UPMC PASTEUR 8640, F-75231 Paris, France

[3] UMR 176, F-75248 Paris, France

[4] Ecole Normale Super, Dept Chim, UMR CNRS UPMC ENS Lab Biomol 7203, F-75231 Paris, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 37期

关键词：

caging groups; fluorescence; imaging agents; kinetics; self-immolative spacers; PHOTOCHEMICAL CONTROL; RELEASE; DENDRIMERS; CHEMISTRY; LIGANDS; DESIGN; SYSTEM;

D O I：

10.1002/anie.201204032

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dual photoliberation: A caged, branched, self-immolative spacer (see scheme, gray box) was designed to rapidly and simultaneously release a desired compound (green) and a fluorophore (red) upon photoactivation. Careful kinetic analysis of the disassembly of the spacer shows that it occurs on the shortest time scale reported to date. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9344 / 9347

页数：4

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