DISEASE MECHANISMS Genetic architectures of psychiatric disorders: the emerging picture and its implications

被引：851

作者：

Sullivan, Patrick F. ^{[1
,2
]}

Daly, Mark J. ^{[3
]}

O'Donovan, Michael ^{[4
]}

机构：

[1] Univ N Carolina, Dept Genet, CB 7264, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA

[3] Harvard Univ, Dept Genet, Cambridge, MA 02138 USA

[4] Cardiff Univ, MRC Ctr Neuropsychiat Genet, Cardiff CF14 4XN, S Glam, Wales

来源：

NATURE REVIEWS GENETICS | 2012年 / 13卷 / 08期

基金：

英国惠康基金; 英国医学研究理事会; 美国国家卫生研究院;

关键词：

GENOME-WIDE ASSOCIATION; COPY NUMBER VARIATION; DEFICIT HYPERACTIVITY DISORDER; SEROTONIN TRANSPORTER GENE; INSTITUTES-OF-HEALTH; DE-NOVO MUTATIONS; BIPOLAR-DISORDER; COMMON VARIANTS; SUSCEPTIBILITY LOCI; ALCOHOL DEPENDENCE;

D O I：

10.1038/nrg3240

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Psychiatric disorders are among the most intractable enigmas in medicine. In the past 5 years, there has been unprecedented progress on the genetics of many of these conditions. In this Review, we discuss the genetics of nine cardinal psychiatric disorders (namely, Alzheimer's disease, attention-deficit hyperactivity disorder, alcohol dependence, anorexia nervosa, autism spectrum disorder, bipolar disorder, major depressive disorder, nicotine dependence and schizophrenia). Empirical approaches have yielded new hypotheses about aetiology and now provide data on the often debated genetic architectures of these conditions, which have implications for future research strategies. Further study using a balanced portfolio of methods to assess multiple forms of genetic variation is likely to yield many additional new findings.

引用

页码：537 / 551

页数：15

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