The Expression and Correlation of iNOS and p53 in Oral Squamous Cell Carcinoma

被引：17

作者：

Yang, Lan ^{[1
,2
,3
]}

Wang, Youyuan ^{[4
]}

Guo, Lvhua ^{[3
]}

Wang, Liping ^{[3
]}

Chen, Weiliang ^{[4
]}

Shi, Bin ^{[1
,2
]}

机构：

[1] Wuhan Univ, Sch & Hosp Stomatol, Minist Educ, State Key Lab Breeding Base Basic Sci Stomatol Hu, Wuhan 430079, Peoples R China

[2] Wuhan Univ, Sch & Hosp Stomatol, Minist Educ, Key Lab Oral Biomed, Wuhan 430079, Peoples R China

[3] Guangzhou Med Univ, Stomatol Hosp, Guangzhou Inst Oral Dis, Key Lab Oral Med, Guangzhou 510140, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou 510120, Guangdong, Peoples R China

来源：

BIOMED RESEARCH INTERNATIONAL | 2015年 / 2015卷

关键词：

NITRIC-OXIDE SYNTHASE; MUTANT P53; CANCER; GAIN; HEAD; ANGIOGENESIS; ACTIVATION; APOPTOSIS; GENE;

D O I：

10.1155/2015/637853

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Oral squamous cell carcinoma (OSCC) is the most prevalent form of oral cancer. Inducible nitric oxide synthase (iNOS) and p53 are associated with a variety of human cancers, but their expression and interaction in OSCC have not been fully explored. In this study, we investigated the expression of iNOS and p53 in OSCC and their correlation with tumor development and prognosis. In addition, we explored the interaction of iNOS and p53 in OSCC. The expression of iNOS and p53 in OSCC was investigated using immunohistochemical method and their interaction was studied using RNAi technique. Our results showed that the expression of both iNOS and p53 was significantly correlated with tumor stages and pathological grade of OSCC (P < 0.05). In contrast, there was no correlation between iNOS and p53 expression and lymph node metastasis (P < 0.05). The OSCC survival rate was negatively associated with iNOS expression, but not with p53. A significant increase in the expression of the p53 was observed when iNOS expression was knocked down. The immunoexpression of iNOS is correlated with tumorigenesis and prognosis of OSCC and may serve as a prognostic marker.

引用

页数：8

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