Vitamin D and Diabetes

被引：204

作者：

Mitri, Joanna ^{[1
]}

Pittas, Anastassios G. ^{[2
]}

机构：

[1] Prima CARE Med Ctr, Div Endocrinol Diabet & Metab, Fall River, MA 02721 USA

[2] Tufts Med Ctr, Div Endocrinol Diabet & Metab, Boston, MA 02111 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2014年 / 43卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Vitamin D; Type; 2; diabetes; Insulin resistance; Insulin sensitivity; 25-hydroxyvitamin D; CYTOSOLIC-FREE CALCIUM; SERUM 25-HYDROXYVITAMIN D; PLACEBO-CONTROLLED TRIAL; BETA-CELL FUNCTION; CARDIOVASCULAR RISK-FACTORS; CYTOKINE-INDUCED APOPTOSIS; INSULIN-RECEPTOR GENE; 1,25-DIHYDROXYVITAMIN D-3; D SUPPLEMENTATION; METABOLIC SYNDROME;

D O I：

10.1016/j.ecl.2013.09.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There has been increasing evidence that vitamin D may have a role in modifying risk of diabetes. Vitamin D has both direct and indirect effects on various mechanisms related to the pathophysiology of type 2 diabetes, including pancreatic beta cell dysfunction, impaired insulin action and systemic inflammation. This article describes the biologic plausibility behind the potential association between vitamin D and type 2 diabetes and summarizes the current evidence from human studies that suggests but does not prove a relation between vitamin D and type 2 diabetes, and briefly reports on the potential association between vitamin D and type 1 diabetes.

引用

页码：205 / +

页数：29

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