Aortic Arterial Stiffness is a Moderate Predictor of Cardiovascular Disease in Patients With Psoriasis Vulgaris

被引：60

作者：

Balta, Ilknur ^{[1
]}

Balta, Sevket ^{[2
]}

Demirkol, Sait ^{[2
]}

Celik, Turgay ^{[2
]}

Ekiz, Ozlem ^{[3
]}

Cakar, Mustafa ^{[4
]}

Sarlak, Hakan ^{[4
]}

Ozoguz, Pinar ^{[5
]}

Iyisoy, Atila ^{[2
]}

机构：

[1] Kecioren Training & Res Hosp, Dept Dermatol, Ankara, Turkey

[2] Gulhane Mil Med Acad, Dept Cardiol, Ankara, Turkey

[3] Mustafa Kemal Univ, Dept Dermatol, Antakya, Turkey

[4] Gulhane Mil Med Acad, Dept Internal Med, Ankara, Turkey

[5] Afyon Kocatepe Univ, Dept Dermatol, Afyon, Turkey

来源：

ANGIOLOGY | 2014年 / 65卷 / 01期

关键词：

psoriasis; arterial stiffness; high-sensitivity C-reactive protein; endothelial dysfunction; atherosclerosis; RHEUMATOID-ARTHRITIS; MYOCARDIAL-INFARCTION; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME; RISK-FACTORS; ASSOCIATION; PREVALENCE;

D O I：

10.1177/0003319713485805

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Psoriasis is associated with an increased risk of atherosclerosis. Endothelial dysfunction is the critical early step in the process of atherogenesis, and it is commonly investigated by measuring arterial stiffness. We aimed to investigate the relationship between arterial stiffness and high-sensitivity C-reactive protein (hsCRP) in patients with psoriasis. A total of 32 patients with psoriasis and 35 patients with other skin diseases were included in the study. The hsCRP levels and arterial stiffness measurements were compared. Arterial stiffness was significantly different between the 2 groups (P = .01). Arterial stiffness was not associated with the duration of the disease or the disease activity (P = .34 and .64, respectively). In patients with psoriasis, arterial stiffness correlated positively with age, sex, body mass index, diastolic blood pressure, and hsCRP level (P < .05). These findings provide further evidence of a link between inflammation, premature atherosclerosis, and psoriasis.

引用

页码：74 / 78

页数：5

共 30 条

[1] Psoriasis is associated with clinically significant cardiovascular risk: a Danish nationwide cohort study [J].

Ahlehoff, O. ;

Gislason, G. H. ;

Charlot, M. ;

Jorgensen, C. H. ;

Lindhardsen, J. ;

Olesen, J. B. ;

Abildstrom, S. Z. ;

Skov, L. ;

Torp-Pedersen, C. ;

Hansen, P. R. .

JOURNAL OF INTERNAL MEDICINE, 2011, 270 (02) :147-157

[2] Psoriasis and metabolic syndrome: A systematic review and meta-analysis of observational studies [J].

Armstrong, April W. ;

Harskamp, Caitlin T. ;

Armstrong, Ehrin J. .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2013, 68 (04) :654-662

[3] Non-dipping nocturnal blood pressure in psoriasis vulgaris [J].

Bacaksiz, Ahmet ;

Vatankulu, Mehmet Akif ;

Sonmez, Osman ;

Erdogan, Ercan ;

Tasal, Abdurrahman ;

Turfan, Murat ;

Ertas, Gokhan ;

Sevgili, Emrah ;

Dizman, Didem ;

Onsun, Nahide .

WIENER KLINISCHE WOCHENSCHRIFT, 2012, 124 (23-24) :822-829

[4] Increased carotid artery intima-media thickness and impaired endothelial function in psoriasis [J].

Balci, D. D. ;

Balci, A. ;

Karazincir, S. ;

Ucar, E. ;

Iyigun, U. ;

Yalcin, F. ;

Seyfeli, E. ;

Inandi, T. ;

Egilmez, E. .

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2009, 23 (01) :1-6

[5]

Balta S, 2013, ANGIOLOGY

[6]

Balta S, 2013, J CLIN HYPERTENS GRE

[7] TNF-alpha blockade induces a reversible but transient effect on endothelial dysfunction in patients with long-standing severe rheumatoid arthritis [J].

Bosello, Silvia ;

Santoliquido, Angelo ;

Zoli, Angelo ;

Di Campli, Cristiana ;

Flore, Roberto ;

Tondi, Paolo ;

Ferraccioli, GianFranco .

CLINICAL RHEUMATOLOGY, 2008, 27 (07) :833-839

[8] Psoriatic arthritis is associated with increased arterial stiffness in the absence of known cardiovascular risk factors: a case control study [J].

Costa, Luisa ;

Caso, Francesco ;

D'Elia, Lanfranco ;

Atteno, Mariangela ;

Peluso, Rosario ;

Del Puente, Antonio ;

Strazzullo, Pasquale ;

Scarpa, Raffaele .

CLINICAL RHEUMATOLOGY, 2012, 31 (04) :711-715

[9]

Demirkol S, 2012, CLIN APPL THROMB HEM

[10] The effect of smoking on arterial stiffness [J].

Doonan, Robert J. ;

Hausvater, Anais ;

Scallan, Ciaran ;

Mikhailidis, Dimitri P. ;

Pilote, Louise ;

Daskalopoulou, Stella S. .

HYPERTENSION RESEARCH, 2010, 33 (05) :398-410

← 1 2 3 →