Indoor, outdoor, and personal exposure to PM2.5 and their bioreactivity among healthy residents of Hong Kong

被引:29
|
作者
Chen, Xiao-Cui [1 ,10 ,11 ]
Chuang, Hsiao-Chi [2 ]
Ward, Tony J. [3 ]
Tian, Linwei [4 ]
Cao, Jun-Ji [5 ,6 ]
Ho, Steven Sai-Hang [12 ,13 ]
Lau, Ngar-Cheung [1 ,7 ]
Hsiao, Ta-Chih [9 ]
Yim, Steve H. L. [1 ,7 ]
Ho, Kin-Fai [1 ,8 ]
机构
[1] Chinese Univ Hong Kong, Inst Environm Energy & Sustainabil, Hong Kong, Peoples R China
[2] Taipei Med Univ, Coll Med, Sch Resp Therapy, Taipei, Taiwan
[3] Univ Montana, Sch Publ & Community Hlth Sci, Missoula, MT 59812 USA
[4] Univ Hong Kong, Sch Publ Hlth, Hong Kong, Peoples R China
[5] Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol, SKLLQG, Xian, Peoples R China
[6] Xi An Jiao Tong Univ, Inst Global Environm Change, Xian, Peoples R China
[7] Chinese Univ Hong Kong, Dept Geog & Resource Management, Hong Kong, Peoples R China
[8] Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China
[9] Natl Taiwan Univ, Grad Inst Environm Engn, Taipei, Taiwan
[10] Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen, Peoples R China
[11] Univ Hong Kong, Hlth High Dens Cities Lab, HKUrbanLab, Hong Kong, Peoples R China
[12] Desert Res Inst, Div Atmosphere Sci, Reno, NV 89512 USA
[13] Hong Kong Premium Serv & Res Lab, Kowloon, Cheung Sha Wan, Hong Kong, Peoples R China
关键词
Organic carbon; PAHs; Inflammation; Oxidative stress; Biomarkers; FINE PARTICULATE MATTER; POLYCYCLIC-AROMATIC-HYDROCARBONS; OXIDATIVE STRESS; AIR-POLLUTION; PARTICLES PM2.5; INDOOR/OUTDOOR RELATIONSHIPS; CIRCULATING BIOMARKERS; CHINESE MEGACITY; RISK-ASSESSMENT; AMBIENT;
D O I
10.1016/j.envres.2020.109780
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Direct evidence about associations between fine particles (PM2.5) components and the corresponding PM2.5 bioreactivity at the individual level is limited. We conducted a panel study with repeated personal measurements involving 56 healthy residents in Hong Kong. Fractional exhaled nitric oxide (FeNO) levels were measured from these subjects. Out of 56 subjects, 27 (48.2%) participated in concurrent outdoor, indoor, and personal PM2.5 monitoring. Organic carbon (OC), elemental carbon (EC), particle bound-polycyclic aromatic hydrocarbons (PAHs), and phthalates were analyzed. Alteration in cell viability, lactic dehydrogenase (LDH), interleukin-6 (IL-6), and 8-isoprostane by 50 mu g/mL PM2.5 extracts was determined in A549 cells in vitro. Moderate heterogeneities were shown in PM2.5 exposures and the corresponding PM2.5 bioreactivity across different sample types. Associations between the analyzed components and PM2.5 bioreactivity were assessed using the multiple regression models. Toxicological results revealed that indoor and personal exposure to OC as well as PAH compounds and their derivatives (e.g., Alkyl-PAHs, Oxy-PAHs) induced cell viability reduction and increase in levels of LDH, IL-6, and 8-isoprostane. Overall, OC in personal exposure played a dominant role in PM2.5-induced bioreactivity. Subsequently, we examined the associations of FeNO with IL-6 and 8-isoprostane levels using mixed-effects models. The results showed that per interquartile change in IL-6 and 8-isoprostane were associated with a 6.4% (p < 0.01) and 11.1% (p < 0.01) increase in FeNO levels, respectively. Our study explored the toxicological properties of chemical components in PM2.5 exposure, which suggested that residential indoors and personal OC and PAHs should be of great concern for human health. These findings indicated that further studies in inflammation and oxidative stress-related illnesses due to particle exposure would benefit from the assessment of in vitro PM2.5 bioreactivity.
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页数:13
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